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Molecular Biology of the Endocannabinoid System 2.0
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Molecular Biology of the Endocannabinoid System 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2063

Special Issue Editor

Dr. Deanne H. Hryciw

E-Mail Website
Guest Editor
School of Environment and Sciences, Griffith University, Nathan, QLD 4111, Australia
Interests: endocannabinoid system; development; cell signalling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The endocannabinoid system (ECS) plays a key role in maintaining cellular and tissue physiology, and dysfunction of endocannabinoid signalling is associated with disease. The ECS is comprised of endocannabinoids, which are widely distributed in many tissues, as well as the enzymes responsible for their degradation and synthesis, and the receptors that endocannabinoids bind to. Emerging research has shown that the ECS has therapeutic potential, and targeting the ECS can rescue several disorders, with cannabis for medical and recreational purposes being legalized in many countries. Contributions are invited from investigators worldwide in the form of reviews or original research articles on the molecular biology of the endocannabinoid system and mechanisms through which cannabinoid signalling modulates human health, and its role in disease. These can be utilising in vitro or in vivo systems.

Dr. Deanne H. Hryciw
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cannabinoid receptors
  • cannabinoid signalling
  • cannabinoid therapeutics
  • physiology
  • development
  • disease
  • organs

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Published Papers (1 paper)

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Research

11 pages, 2485 KiB  
Article
Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model
by Nirajan Shrestha, Simone L. Sleep, Olivia J. Holland, Josif Vidimce, Andrew C. Bulmer, James S. M. Cuffe, Anthony V. Perkins, Andrew J. McAinch and Deanne H. Hryciw
Int. J. Mol. Sci. 2024, 25(2), 1129; https://doi.org/10.3390/ijms25021129 - 17 Jan 2024
Viewed by 713
Abstract
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters cardiovascular development in adolescent rats and hepatic function in adult rats in a sex-specific manner. We investigated the effects of [...] Read more.
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters cardiovascular development in adolescent rats and hepatic function in adult rats in a sex-specific manner. We investigated the effects of an HLA diet on adolescent offspring hepatic lipids and hepatic lipid metabolism gene expression, and the ability of the postnatal diet to alter these effects. Female Wistar Kyoto rats were fed low LA (LLA; 1.44% energy from LA) or high LA (HLA; 6.21% energy from LA) diets during pregnancy and gestation/lactation. Offspring, weaned at postnatal day (PN) 25, were fed LLA or HLA and euthanised at PN40 (n = 6–8). Maternal HLA increased circulating uric acid, decreased hepatic cholesterol and increased hepatic Pparg in males, whereas only hepatic Srebf1 and Hmgcr increased in females. Postnatal (post-weaning) HLA decreased liver weight (% body weight) and increased hepatic Hmgcr in males, and decreased hepatic triglycerides in females. Maternal and postnatal HLA had an interaction effect on Lpl, Cpt1a and Pparg in females. These findings suggest that an HLA diet both during and after pregnancy should be avoided to improve offspring disease risk. Full article
(This article belongs to the Special Issue Molecular Biology of the Endocannabinoid System 2.0)
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