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Special Issue "Vitamins and Derived Cofactors: Transport, Metabolism, Assembly and Deficiencies"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 December 2023 | Viewed by 205

Special Issue Editors

Department of Bioscience, Biotechnology and Biopharmaceutics, University of Bari A. Moro, Via Orabona, 4, I-70126 Bari, Italy
Interests: Rf and derived cofactors; transport metabolism; cofactor assembly; related human disorders
Special Issues, Collections and Topics in MDPI journals
Department DiBEST (Biologia, Ecologia, Scienze della Terra), Unity of Molecular Biology, University of Calabria, Via P. Bucci 6C, 87036 Arcavacata di Rende, Italy
Interests: protein expression and purification; structure function studies; FAD synthase isoforms; SLC transporters; enzymes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The intra-cellular availability of vitamin-derived cofactors is strictly required for the correct structure and function of a great number of enzymes in all living organisms. Nevertheless, many aspects concerning vitamins and/or their derived cofactor absorption, transport, metabolism and intracellular trafficking are still awaiting elucidation, as well as the mode of insertion of cofactors into nascent polypeptides. Given the relevance of these essential molecules for cellular functionality, it is not surprising that a number of severe human pathological conditions, such as cancer, neurodegeneration and certain inborn errors of metabolism, are related to alterations to cofactor availability; therefore, further research is necessary to define the molecular consequences of alterations to the individual steps of cofactor delivery to search for a possible therapeutic intervention on the related pathologies.

This Special Issue aims to provide a sort of compendium on the recent advances in the fields of enzymology, cellular biochemistry and molecular biology related to vitamins and their derived cofactors. Considering the wide spectrum of functions that cofactor-requiring enzymes can have in cells, the translation of basic knowledge to pharmacology and pathophysiology will also be addressed.

Prof. Dr. Maria Barile
Prof. Michele Galluccio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • vitamin
  • cofactor
  • transporter
  • assembly
  • vitamin-responsive inborn errors of metabolism

Published Papers

This special issue is now open for submission.
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