Special Issue "Vitamins and Derived Cofactors: Transport, Metabolism, Assembly and Deficiencies"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 December 2023 | Viewed by 205
Special Issue Editors
Interests: Rf and derived cofactors; transport metabolism; cofactor assembly; related human disorders
Special Issues, Collections and Topics in MDPI journals
Interests: protein expression and purification; structure function studies; FAD synthase isoforms; SLC transporters; enzymes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The intra-cellular availability of vitamin-derived cofactors is strictly required for the correct structure and function of a great number of enzymes in all living organisms. Nevertheless, many aspects concerning vitamins and/or their derived cofactor absorption, transport, metabolism and intracellular trafficking are still awaiting elucidation, as well as the mode of insertion of cofactors into nascent polypeptides. Given the relevance of these essential molecules for cellular functionality, it is not surprising that a number of severe human pathological conditions, such as cancer, neurodegeneration and certain inborn errors of metabolism, are related to alterations to cofactor availability; therefore, further research is necessary to define the molecular consequences of alterations to the individual steps of cofactor delivery to search for a possible therapeutic intervention on the related pathologies.
This Special Issue aims to provide a sort of compendium on the recent advances in the fields of enzymology, cellular biochemistry and molecular biology related to vitamins and their derived cofactors. Considering the wide spectrum of functions that cofactor-requiring enzymes can have in cells, the translation of basic knowledge to pharmacology and pathophysiology will also be addressed.
Prof. Dr. Maria Barile
Prof. Michele Galluccio
Guest Editors
Manuscript Submission Information
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Keywords
- vitamin
- cofactor
- transporter
- assembly
- vitamin-responsive inborn errors of metabolism
