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Olive Oil and Derivatives for Human Health
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Olive Oil and Derivatives for Human Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 10 May 2024 | Viewed by 3952

Special Issue Editor

Prof. Dr. Amal Kaddoumi

E-Mail Website
Guest Editor
Harrison College of Pharmacy, Department of Drug Discovery and Development, Auburn University, Auburn, AL 36849, USA
Interests: Alzheimer's disease; cerebral amyloid angiopathy; blood-brain barrier; neuroinflammation; amyloid-beta
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to contribute to our Special Issue in the International Journal of Molecular Sciences (IJMS) entitled “Olive Oil and Derivatives for Human Health”. This Special Issue will cover a selection of recent research topics and current review articles reporting the latest updates related to olive oil and human health.

Traditionally, olive oil has been known as one of the main elements of the Mediterranean diet, which recently became popular worldwide. Olive oil is well recognized for its beneficial effect on health. Several epidemiological and clinical studies have linked olive oil intake with lower total mortality and disease-specific mortality caused by cardiovascular, cancer, and neurodegenerative diseases. Olive oil constitutes two major components: monounsaturated fatty acids and bioactive phenolic compounds, individually and collectively responsible for olive oil’s health-promoting properties. Several preclinical and clinical studies have reported the protective effects of olive oil and its phenolic compounds, which have been attributed to various mechanisms. In addition to its lipid- and blood glucose-lowering effects, olive oil possesses anti-inflammatory and antioxidant effects.

This Special Issue focuses on preclinical research utilizing in vitro and in vivo models, genetics, molecular biology, cell biology, neuroimmunology, and pharmacology approaches to recognize olive oil, its phenolic compounds, and other derivatives’ roles in human health and disease protection. While clinical trials are not the focus of this Special Issue, clinical trials with mechanistic studies are welcome.

Prof. Dr. Amal Kaddoumi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extra-virgin olive oil
  • olive oil
  • oleic acid
  • EVOO phenolics
  • oleocanthal
  • olive leaf extract
  • human diseases
  • neurodegenerative diseases
  • cardiovascular disease
  • cancer
  • mechanism of action

Published Papers (2 papers)

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Research

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21 pages, 3084 KiB  
Article
Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic Patients: A Postprandial Study
by Maria Efthymia Katsa, Kleopatra Ketselidi, Marianna Kalliostra, Anastasios Ioannidis, Andrea Paola Rojas Gil, Panagiotis Diamantakos, Eleni Melliou, Prokopios Magiatis and Tzortzis Nomikos
Int. J. Mol. Sci. 2024, 25(2), 908; https://doi.org/10.3390/ijms25020908 - 11 Jan 2024
Viewed by 829
Abstract
Postprandial dysmetabolism is a common entity of type 2 diabetes mellitus (T2DM) and may act as a daily stressor of the already dysfunctional diabetic platelets. This study aims to investigate whether oleocanthal-rich olive oils (OO), incorporated into a carbohydrate-rich meal, can affect postprandial [...] Read more.
Postprandial dysmetabolism is a common entity of type 2 diabetes mellitus (T2DM) and may act as a daily stressor of the already dysfunctional diabetic platelets. This study aims to investigate whether oleocanthal-rich olive oils (OO), incorporated into a carbohydrate-rich meal, can affect postprandial dysmetabolism and platelet aggregation. Oleocanthal is a cyclooxygenase inhibitor with putative antiplatelet properties. In this randomized, single-blinded, crossover study, ten T2DM patients consumed five isocaloric meals containing 120 g white bread combined with: (i) 39 g butter, (ii) 39 g butter and 400 mg ibuprofen, (iii) 40 mL OO (phenolic content < 10 mg/Kg), (iv) 40 mL OO with 250 mg/Kg oleocanthal and (v) 40 mL OO with 500 mg/Kg oleocanthal. Metabolic markers along with ex vivo ADP- and thrombin receptor-activating peptide (TRAP)-induced platelet aggregation were measured before and for 4 h after the meals. The glycemic and lipidemic response was similar between meals. However, a sustained (90–240 min) dose-dependent reduction in platelets’ sensitivity to both ADP (50–100%) and TRAP (20–50%) was observed after the oleocanthal meals in comparison to OO or butter meals. The antiplatelet effect of the OO containing 500 mg/Kg oleocanthal was comparable to that of the ibuprofen meal. In conclusion, the consumption of meals containing oleocanthal-rich OO can reduce platelet activity during the postprandial period, irrespective of postprandial hyperglycemia and lipidemia. Full article
(This article belongs to the Special Issue Olive Oil and Derivatives for Human Health)
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Review

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20 pages, 2427 KiB  
Review
Extra-Virgin Olive Oil in Alzheimer’s Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies
by Amer E. Alkhalifa, Nour F. Al-Ghraiybah and Amal Kaddoumi
Int. J. Mol. Sci. 2024, 25(3), 1914; https://doi.org/10.3390/ijms25031914 - 05 Feb 2024
Viewed by 2201
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier (BBB) dysfunction, increased oxidative stress, and neuroinflammation. Current treatment options include monoclonal antibody drugs, acetylcholinesterase, and n-methyl-d-aspartate [...] Read more.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier (BBB) dysfunction, increased oxidative stress, and neuroinflammation. Current treatment options include monoclonal antibody drugs, acetylcholinesterase, and n-methyl-d-aspartate (NMDA) antagonists. Although those treatments provide some improvements in patients’ quality of life, they fail to prevent or cure AD. Current research aims to identify novel targets and tools for AD prevention and modification. In this context, several studies showed the beneficial effect of the Mediterranean diet in the prevention and treatment of AD. One integral component of the Mediterranean diet is olive oil and extra-virgin olive oil (EVOO), which is high in phenolic compounds. EVOO and other olive-related phenolic compounds have been shown to reduce the risk of developing mild cognitive impairment (MCI) and AD. In this review, we discuss the mechanisms by which EVOO and phenolic compounds exert neuroprotective effects, including modulation of AD pathologies and promotion of cognitive health. Findings indicate that EVOO and its phenolic constituents influence key pathological processes of AD, such as Aβ aggregation, tau phosphorylation, and neuroinflammation, while also enhancing BBB integrity and reducing oxidative stress. The human studies cited reveal a consistent trend where the consumption of olive oil is associated with cognitive benefits and a decreased risk of AD and related dementias. In conclusion, EVOO and its phenolic compounds hold promising potential for the prevention and treatment of AD, representing a significant shift towards more effective strategies against this complex neurodegenerative disorder. Full article
(This article belongs to the Special Issue Olive Oil and Derivatives for Human Health)
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