Neuroinflammation in the Pathogenesis of Alzheimer’s Disease and Related Dementias: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 56
Special Issue Editor
Interests: Alzheimer's disease; cerebral amyloid angiopathy; blood-brain barrier; neuroinflammation; amyloid-beta
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue on “Neuroinflammation in the Pathogenesis of Alzheimer’s Disease and Related Dementias”.
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. In addition to memory loss and progressive dementia, AD is characterized by several pathological hallmarks including the deposition of amyloid-β(Aβ) plaques, neurofibrillary tangles (NFT) of hyper-phosphorylated tau, blood–brain barrier breakdown, oxidative stress, and neuronal loss. In addition, neuroinflammation has a prominent role in the pathogenesis of AD, as suggested by the increased levels of inflammatory markers in AD patients as well as findings from genome-wide association studies exploring the involvement of various single-nucleotide polymorphisms of genes related to neuroinflammation with the risk of developing AD. Inflammation in the brain has an important neuroprotective role during the acute-phase response; however, in the long term, neuroinflammation becomes detrimental. The activation of microglia and astrocytes triggers an innate immune response to release various pro-inflammatory mediators and toxic products such as reactive oxygen species and cytokines, which could collectively increase Aβproduction and tau hyper-phosphorylation, and thus contribute to disease progression and severity. Modulating the release of neuroinflammatory molecules and targeting pathological gliosis represent a valuable therapeutic approach and may have beneficial effects on the onset, progress, and severity of AD. In addition, external factors such as systemic inflammation, diabetes, and obesity could interfere with immunological processes of the brain and further promote disease progression; hence, the modulation of risk factors could lead to preventive strategies for AD.
We are pleased to invite you to participate in this Special Issue through research articles, comprehensive reviews, or short communications about neuroinflammation in AD, treatments targeting neuroinflammation, and related topics.
Prof. Dr. Amal Kaddoumi
Guest Editor
Manuscript Submission Information
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Keywords
- Alzheimer’s disease
- neuroinflammation
- drug development
- microglia
- astrocytes
- cytokines
- TREM2
- risk factors
- biomarkers
