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Infectious Agents and Inflammatory Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 3667

Special Issue Editor

Special Issue Information

Dear Colleagues,

Chronic inflammatory diseases, affecting the different parts of the human body, including the central nervous system as well as the respiratory, intestinal, vascular and genital tracts, represent an important public health problem due to their contribution to elevated morbidity and mortality, as evidenced by the latest report of the World Health Organization. In recent years, infectious agents, including viral and bacterial pathogens, as well as the presence of more infectious agents (a condition called “infectious burden”) have acquired increasing importance in the etiopathogenesis of chronic conditions such as atherosclerosis, irritable bowel syndrome, Chron’s disease, pelvic inflammatory disease, cancer, etc. This Special Issue welcomes current knowledge and research trends on the epidemiological, clinical, cellular and molecular aspects concerning the etiopathogenetic role of invading pathogens in the onset, development, and outcome of these conditions. Original research articles as well as review, systematic review and communication are encouraged.

Dr. Rosa Sessa
Guest Editor

Manuscript Submission Information

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Keywords

  • bacteria
  • viruses
  • infectious burden
  • host–pathogen interactions
  • epidemiological studies
  • prevention studies
  • cellular and molecular mechanisms
  • chronic inflammatory diseases
  • atherosclerosis
  • chronic obstructive pulmonary disease
  • inflammatory bowel diseases
  • irritable bowel syndrome
  • pelvic inflammatory disease
  • Parkinson’s disease
  • Alzheimer’s disease
  • cancer

Published Papers (1 paper)

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Review

21 pages, 1974 KiB  
Review
Immunopathogenesis of Atopic Dermatitis: Focus on Interleukins as Disease Drivers and Therapeutic Targets for Novel Treatments
by Karolina Makowska, Joanna Nowaczyk, Leszek Blicharz, Anna Waśkiel-Burnat, Joanna Czuwara, Małgorzata Olszewska and Lidia Rudnicka
Int. J. Mol. Sci. 2023, 24(1), 781; https://doi.org/10.3390/ijms24010781 - 02 Jan 2023
Cited by 12 | Viewed by 3330
Abstract
Atopic dermatitis is a chronic, recurrent inflammatory skin disorder manifesting by eczematous lesions and intense pruritus. Atopic dermatitis develops primarily as a result of an epidermal barrier defect and immunological imbalance. Advances in understanding these pathogenetic hallmarks, and particularly the complex role of [...] Read more.
Atopic dermatitis is a chronic, recurrent inflammatory skin disorder manifesting by eczematous lesions and intense pruritus. Atopic dermatitis develops primarily as a result of an epidermal barrier defect and immunological imbalance. Advances in understanding these pathogenetic hallmarks, and particularly the complex role of interleukins as atopic dermatitis drivers, resulted in achieving significant therapeutic breakthroughs. Novel medications involve monoclonal antibodies specifically blocking the function of selected interleukins and small molecules such as Janus kinase inhibitors limiting downstream signaling to reduce the expression of a wider array of proinflammatory factors. Nevertheless, a subset of patients remains refractory to those treatments, highlighting the complexity of atopic dermatitis immunopathogenesis in different populations. In this review, we address the immunological heterogeneity of atopic dermatitis endotypes and phenotypes and present novel interleukin-oriented therapies for this disease. Full article
(This article belongs to the Special Issue Infectious Agents and Inflammatory Diseases)
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