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Gut Microbiota and Food Ingredients
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Gut Microbiota and Food Ingredients

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (20 March 2023) | Viewed by 7153

Special Issue Editors

Prof. Dr. Wen-Yong Lou

E-Mail Website
Guest Editor
College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: biocatalysis and biotransformation in novel solvent media; development of novel biocatalysts by chemical engineering and biotechnology; immobilization of enzyme on/into novel carriers for catalysis; food microbiology and nutrition; chemistry and biotechnology of natural products
Prof. Dr. Xuewu Zhang

E-Mail Website
Guest Editor
College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: food nutrition and health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Here a food ingredient is any substance that is added to foods to exert health benefit, including bioactive natural products, probiotics, prebiotics and nutraceuticals. Increasing in vivo and vitro studies have suggested that the oral bioactive compounds and nutraceuticals can directly improve anti-cancer, anti-immune-response, anti-bacterial, or antioxidant abilities. While recently it was also shown that the importance of daily diet in regulating gut microbiota and the associations of gut microbial dysbiosis with prevalent metabolic diseases. Thus, there is an urgent need to further link the gut microbiota to various food ingredients, which have been implicated in diabetes, obesity, hyperuricemia, cardiovascular and other metabolic diseases.

The Special Issue entitled ‘Gut microbiota and Food Ingredients’ will discuss the recent advances in molecular mechanism that control gut microbiota development in diet-effect-health line to understand how the human gut microbiome responds to food ingredients and how the microbial alterations are related to the metabolic benefits of food ingredients. Both relative reviews and research papers are welcome. 

Prof. Dr. Wen-Yong Lou
Prof. Dr. Xuewu Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

16 pages, 4801 KiB  
Article
Polypeptides Isolated from Lactococcus lactis Alleviates Lipopolysaccharide (LPS)-Induced Inflammation in Ctenopharyngodon idella
by Pei Li, Youqing Xu, Yupo Cao and Zhaokun Ding
Int. J. Mol. Sci. 2022, 23(12), 6733; https://doi.org/10.3390/ijms23126733 - 16 Jun 2022
Cited by 1 | Viewed by 1450
Abstract
The main purpose of the present study was to evaluate the anti-inflammatory activity of Lactococcus lactis BL52 and isolate active substances responsible for anti-inflammatory activity. Head-kidney (HK) macrophages were used for in vitro bioassay-guided isolation, and the structure of the two peptides was [...] Read more.
The main purpose of the present study was to evaluate the anti-inflammatory activity of Lactococcus lactis BL52 and isolate active substances responsible for anti-inflammatory activity. Head-kidney (HK) macrophages were used for in vitro bioassay-guided isolation, and the structure of the two peptides was identified by mass spectrometry analysis. Lipopolysaccharide (LPS)-induced inflammatory responses in Ctenopharyngodon idella were also examined to evaluate the in vivo anti-inflammatory activity of active substances. Two active peptides were isolated by HPLC from L. lactis BL52, and an in vitro anti-inflammatory assay demonstrated that peptide ALBL1 and ALBL2 dose-dependently inhibited LPS-induced inflammatory cytokines TNF-α, IL-6, and IL-1β and inflammatory factors NO and PGE 2 production in macrophages (p < 0.05). After being treated with 20 mg/Kg peptide ALBL1 and ALBL2, the expression levels of TNF-α, IL-6, IL-1β, NO, and PGE 2 were significantly inhibited (p < 0.05). Results from the in vivo test showed that when the concentration of peptide ALBL1 and ALBL2 reached 30 mg/Kg, the LPS-induced upregulations of TNF-α, IL-6, IL-1β, NO, and PGE 2 were prevented. In addition, peptide ALBL1 and ALBL2 blocked the expression of Toll-like receptor 2 (TLR2) and then suppressed the phosphorylation of nuclear transcription factor-kappa B (NF-κB) p65 and degradation inhibitor of IκBα. Moreover, C. idella treated with peptide ALBL1 and ALBL2 can relieve pathological inflammatory responses caused by LPS. These results suggest that the anti-inflammatory properties of peptide ALBL1 and ALBL2 might be a result from the inhibition of IL-6, IL-1β, and TNF-α expressions through the downregulation of Toll2/NF-κB signaling pathways. Full article
(This article belongs to the Special Issue Gut Microbiota and Food Ingredients)
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16 pages, 4858 KiB  
Article
High-Amylose Corn Starch Regulated Gut Microbiota and Serum Bile Acids in High-Fat Diet-Induced Obese Mice
by Jiamiao Hu, Peiying Zheng, Jinhui Qiu, Qingyan Chen, Shaoxiao Zeng, Yi Zhang, Shaoling Lin and Baodong Zheng
Int. J. Mol. Sci. 2022, 23(11), 5905; https://doi.org/10.3390/ijms23115905 - 25 May 2022
Cited by 9 | Viewed by 2338
Abstract
High-amylose corn starch is well known for its anti-obesity activity, which is mainly based on the regulatory effects on gut microbiota. Recently, the gut microbiota has been reported to improve metabolic health by altering circulating bile acids. Therefore, in this study, the influence [...] Read more.
High-amylose corn starch is well known for its anti-obesity activity, which is mainly based on the regulatory effects on gut microbiota. Recently, the gut microbiota has been reported to improve metabolic health by altering circulating bile acids. Therefore, in this study, the influence of high-amylose corn starch (HACS) on intestinal microbiota composition and serum bile acids was explored in mice fed with a high fat diet (HFD). The results demonstrated HACS treatment reduced HFD-induced body weight gain, hepatic lipid accumulation, and adipocyte hypertrophy as well as improved blood lipid profiles. Moreover, HACS also greatly impacted the gut microbiota with increased Firmicutes and decreased Bacteroidetes relative abundance being observed. Furthermore, compared to ND-fed mice, the mice with HFD feeding exhibited more obvious changes in serum bile acids profiles than the HFD-fed mice with the HACS intervention, showing HACS might restore HFD-induced alterations to bile acid composition in blood. In summary, our results suggested that the underlying mechanisms of anti-obesity activity of HACS may involve its regulatory effects on gut microbiota and circulating bile acids. Full article
(This article belongs to the Special Issue Gut Microbiota and Food Ingredients)
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13 pages, 3769 KiB  
Article
Histamine Causes Pyroptosis of Liver by Regulating Gut-Liver Axis in Mice
by Qiaoqiao Luo, Ruoyu Shi, Yutong Liu, Libo Huang, Wei Chen and Chengtao Wang
Int. J. Mol. Sci. 2022, 23(7), 3710; https://doi.org/10.3390/ijms23073710 - 28 Mar 2022
Cited by 7 | Viewed by 2070
Abstract
Huangjiu usually caused rapid-drunkenness and components such as β-benzyl ethanol (β-be), isopentanol (Iso), histamine (His), and phenethylamine (PEA) have been reported linked with intoxication. However, the destructive effect of these components on gut microbiota and liver is unclear. In this study, we found [...] Read more.
Huangjiu usually caused rapid-drunkenness and components such as β-benzyl ethanol (β-be), isopentanol (Iso), histamine (His), and phenethylamine (PEA) have been reported linked with intoxication. However, the destructive effect of these components on gut microbiota and liver is unclear. In this study, we found oral treatment of these components, especially His, stimulated the level of oxidative stress and inflammatory cytokines in liver and serum of mice. The gut microbiota community was changed and the level of lipopolysaccharide (LPS) increased significantly. Additionally, cellular pyroptosis pathway has been assessed and correlation analysis revealed a possible relationship between gut microbiota and liver pyroptosis. We speculated oral His treatment caused the reprogramming of gut microbiota metabolism, and increased LPS modulated the gut-liver interaction, resulting in liver pyroptosis, which might cause health risks. This study provided a theoretical basis for the effect of Huangjiu, facilitating the development of therapeutic and preventive strategies for related inflammatory disorders. Full article
(This article belongs to the Special Issue Gut Microbiota and Food Ingredients)
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