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Special Issue "Cyclin-Dependent Kinases: Their Role in Cell Physiology and Pathologies"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 1 March 2024 | Viewed by 126

Special Issue Editors

Dr. Jacek Z. Kubiak
E-Mail Website
Guest Editor
Dynamics and Mechanics of Epithelia Group, Faculty of Medicine, Institute of Genetics and Development of Rennes, University of Rennes, CNRS, UMR 6290, 35043 Rennes, France
Interests: cell cycle regulation; kinases; phosphatases; embryo development; oocytes; cancers
Transplant Immunology, The Houston Methodist Research Institute, Houston, TX 77030, USA
Interests: macrophages; actin cytoskeleton; RhoA pathway; chronic rejection; transplantation; germ cells; Xenopus laevis; development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cyclin-dependent kinases include over 13 highly conserved serine-threonine kinases present in eukaryotic cells and play pivotal roles in cell physiology. The founding member of the CDK family—CDK1—is the major cell-cycle regulatory kinase necessary for both S- and M-phases. Monomeric CDKs have very low activity. They are activated by association with their respective cyclins, which play the roles of regulatory subunits of the CDK/cyclin complexes. CDKs activities are also regulated by phosphorylation/dephosphorylation on particular amino acids and by their association with small proteins that act as CDK inhibitors. Besides the cell cycle, CDKs also regulate transcription, mRNA processing, and cell differentiation. Some CDKs are necessary for the activation of other CDKs. Recent studies have shown the important involvement of CDKs in different human diseases, with cancers being the most obvious. They are also extremely important during embryo development. This Special Issue of IJMS includes a broad range of basic and translational articles, both original research reports and reviews, focused on the latest developments in the regulation of cellular process and molecular pathways involving CDKs. This Issue focuses on the role of CDKs, but papers devoted to their regulatory subunits—cyclins and CDK inhibitors—are also welcomed.

Dr. Jacek Z. Kubiak
Prof. Dr. Malgorzata Kloc
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cyclin-dependent kinases
  • cyclins
  • CDK inhibitors
  • cell cycle
  • cancers
  • transcription
  • mRNA processing
  • differentiation
  • embryo development

Published Papers

This special issue is now open for submission.
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