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Special Issue "Aquatic Organisms Models Dedicated to Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 306

Special Issue Editors

Transplant Immunology, The Houston Methodist Research Institute, Houston, TX 77030, USA
Interests: macrophages; actin cytoskeleton; RhoA pathway; chronic rejection; transplantation; germ cells; Xenopus laevis; development
Special Issues, Collections and Topics in MDPI journals
Dynamics and Mechanics of Epithelia Group, Faculty of Medicine, Institute of Genetics and Development of Rennes, University of Rennes, CNRS, UMR 6290, 35043 Rennes, France
Interests: embryo development; cell cycle; gene regulation; cancer; stem cells; gonads; genetic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aquatic organisms are an irreplaceable source of medicinal drugs and therapeutics, a perfect model system and indicator for many human diseases, and often also a source of remedies for environmental pollutants. As an example, for several decades, the African clawed frog Xenopus laevis has been used for human pregnancy tests. Between the 1940s and 1960s, thousands of frogs were imported to the USA by pharmaceutical companies and injected with pregnant women’s urine. Xenopus frogs are the perfect human ciliary-based model for kidney disease, and the Xenopus sex reversal is an excellent indicator of water contamination with endocrine disruptors that mimic human sex hormones and are present in the majority of cosmetics and everyday products. Zebrafish and squid eyes are a model for human ocular diseases, such as glaucoma, cataracts, photoreceptor degeneration, and cornea and retina disorders. The Atlantic horseshoe crab’s (Limulus polyphemus) blue blood has been the source of limulus amebocyte lysate (LAL) and has been used to test the bacterial contamination of vaccines and medical equipment. Over the past 30 years, scientists have identified over 20,000 novel biochemical compounds from aquatic organisms, and dozens have been tested in clinical trials. Cytarabine and vidarabine isolated from Caribbean sponges are used to treat leukemia and lymphoma, and systematic herpes virus infections, respectively. Ziconotide, a powerful analgesic drug, is isolated from the cone snail, and trabectedin (Yondelis), a marine alkaloid isolated from the tunicate, is used to treat advanced soft-tissue sarcoma and ovarian cancer.

For this Special Issue, we invite research studies and review articles on the recent progress in aquatic organisms as a source of medication for human diseases. In addition, papers on environmental pollutant markers that act as sources of anti-pollutant compounds are also welcome.

Prof. Dr. Malgorzata Kloc
Prof. Dr. Jacek Z. Kubiak
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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