Special Issue "Evolution, Maintenance and Molecular/Cellular Mechanisms of Totipotency, Pluripotency and Cell Stemness"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1202
Special Issue Editor
Interests: macrophages; actin cytoskeleton; RhoA pathway; chronic rejection; transplantation; germ cells; Xenopus laevis; development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cell stemness is the ability for self renewal (immortality) and differentiation into specialized cells. The self renewal/differentation is achieved through asymmetric cell division, which creates offsprings of different fates: one retaining stemness and another differentiating into a specialized cell. Depending on developmental potential, stem cells can be totipotent, pluripotent, or unipotent. Any adult organism has tissue- and organ-specific stem cells necessary for homeostasis and regeneration. Besides naturally occurring stem cells, there are also artificially created stem cells reprogrammed in vitro into the state of pluripotency. Although the whole embryonic development is based on the programmed and tightly regulated switch from the state of stemness and totipotency to the state of differentiation and specialization, and stem cells are also widely used in regenerative medicine, very little is known about the molecules and signaling pathways regulating stemness, asymmetric divisions, self-renewal, and switch between stemness and differentiation. Even less is known about how stemness evolved. For this special issue, we invite original research and review manuscripts which cover molecular and cellular mechanisms of stemness and its evolution.
Prof. Dr. Malgorzata Kloc
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- stemness
- totipotent
- self-renewal
- asymmetric division
