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Special Issue "Evolution, Maintenance and Molecular/Cellular Mechanisms of Totipotency, Pluripotency and Cell Stemness"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1202

Special Issue Editor

Transplant Immunology, The Houston Methodist Research Institute, Houston, TX 77030, USA
Interests: macrophages; actin cytoskeleton; RhoA pathway; chronic rejection; transplantation; germ cells; Xenopus laevis; development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cell stemness is the ability for self renewal (immortality) and differentiation into specialized cells. The self renewal/differentation is achieved through asymmetric cell division, which creates offsprings of different fates: one retaining stemness and another differentiating into a specialized cell. Depending on developmental potential, stem cells can be totipotent, pluripotent, or unipotent. Any adult organism has tissue- and organ-specific stem cells necessary for homeostasis and regeneration. Besides naturally occurring stem cells, there are also artificially created stem cells reprogrammed in vitro into the state of pluripotency. Although the whole embryonic development is based on the programmed and tightly regulated switch from the state of stemness and totipotency to the state of differentiation and specialization, and stem cells are also widely used in regenerative medicine, very little is known about the molecules and signaling pathways regulating stemness, asymmetric divisions, self-renewal, and switch between stemness and differentiation. Even less is known about how stemness evolved. For this special issue, we invite original research and review manuscripts which cover molecular and cellular mechanisms of stemness and its evolution.

Prof. Dr. Malgorzata Kloc
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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  • stemness
  • totipotent
  • self-renewal
  • asymmetric division

Published Papers (1 paper)

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Notch and Wnt Signaling Modulation to Enhance DPSC Stemness and Therapeutic Potential
Int. J. Mol. Sci. 2023, 24(8), 7389; https://doi.org/10.3390/ijms24087389 - 17 Apr 2023
Cited by 1 | Viewed by 976
The Dental Pulp of permanent human teeth is home to stem cells with remarkable multilineage differentiation ability: human Dental Pulp Stem Cells (DPSCs). These cells display a very notorious expression of pluripotency core factors, and the ability to give rise to mature cell [...] Read more.
The Dental Pulp of permanent human teeth is home to stem cells with remarkable multilineage differentiation ability: human Dental Pulp Stem Cells (DPSCs). These cells display a very notorious expression of pluripotency core factors, and the ability to give rise to mature cell lineages belonging to the three embryonic layers. For these reasons, several researchers in the field have long considered human DPSCs as pluripotent-like cells. Notably, some signaling pathways such as Notch and Wnt contribute to maintaining the stemness of these cells through a complex network involving metabolic and epigenetic regulatory mechanisms. The use of recombinant proteins and selective pharmacological modulators of Notch and Wnt pathways, together with serum-free media and appropriate scaffolds that allow the maintenance of the non-differentiated state of hDPSC cultures could be an interesting approach to optimize the potency of these stem cells, without a need for genetic modification. In this review, we describe and integrate findings that shed light on the mechanisms responsible for stemness maintenance of hDPSCs, and how these are regulated by Notch/Wnt activation, drawing some interesting parallelisms with pluripotent stem cells. We summarize previous work on the stem cell field that includes interactions between epigenetics, metabolic regulations, and pluripotency core factor expression in hDPSCs and other stem cell types. Full article
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