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Autophagy and Cellular Oxidative Stress: Molecular Mechanisms and Diagnostic Biomarkers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 113

Special Issue Editors

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98122 Messina, Italy
Interests: inflammation; oxidative stress; reactive oxygen species; cytokines storm; molecular pathways; in vivo models; natural compounds

Special Issue Information

Dear Colleagues,

The objective of this Special Issue is to improve our knowledge regarding the cellular and molecular mechanisms involved in autophagy and oxidative stress. Oxidative stress and redox signaling are largely involved in the etiology of human diseases, where both survival and cell death signaling cascades have been reported to be modulated by reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS activate autophagy, which facilitates cellular adaptation and diminishes oxidative damage by degrading and recycling intracellular damaged macromolecules and dysfunctional organelles; therefore, autophagy is a major cellular defense against oxidative stress, or related conditions that cause accumulation of damaged proteins or organelles.

This Special Issue, presided by Dr. Daniela Impellizzeri and Ramona D’Amico as Guest Editor, and Dr. Rosalba Siracusa as Topical Advisory Panel Member. We welcome research aimed at improving our understanding of molecular mechanisms and biomarkers through which oxidative stress and autophagy regulate human disease. Indeed, the identification of specific biomarkers of oxidative stress and autophagy is of great importance for disease prevention, monitoring disease progression and evaluating the effectiveness of treatments.

We welcome various types of manuscripts, including original research and review articles, clinical trials and instructive case reports.

Dr. Ramona D’Amico
Dr. Daniela Impellizzeri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • autophagy
  • oxidative stress
  • biomarkers
  • acute and chronic diseases
  • molecular pathways
  • ROS
  • mitophagy

Published Papers

This special issue is now open for submission.
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