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Biomedicines
Special Issues
The Reactive Oxygen Species Signaling Pathway: Function and Regulation
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Special Issue "The Reactive Oxygen Species Signaling Pathway: Function and Regulation"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 849

Special Issue Editors

Dr. Tiziana Genovese
E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98122 Messina, Italy
Interests: antioxidant; anti-inflammatory
Special Issues, Collections and Topics in MDPI journals
Dr. Daniela Impellizzeri

E-Mail Website
Guest Editor
Department of Chemical biological, Pharmaceutical and Environmental Sciences, Università degli Studi di Messina, Messina, Italy
Interests: inflammation; oxidative stress; biochemistry; pharmacology; molecular biology
Special Issues, Collections and Topics in MDPI journals
Dr. Rosalba Siracusa

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98122 Messina, Italy
Interests: clinical biochemistry; molecular biology; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The ability of reactive oxygen species (ROS) to activate or deactivate a variety of receptors, proteins, ions, and other signaling molecules (NF-kB, MAPK, Keap1-Nrf2-ARE, and PI3K-Akt) has made it abundantly clear that redox balance plays a critical role in the physiological and pathological events of cells. When the redox balance is disrupted because of excessive accumulation or depletion of ROS, many cellular signaling pathways are affected, resulting in cellular dysfunction and the development of various pathologies such as cardiovascular, metabolic, neurodegenerative, and inflammatory pathologies, as well as those related to aging. The endogenous antioxidant response system, which is mediated by the transcription factor Nrf2, shields cells from oxidative stress by boosting the production of cytoprotective enzymes. Nrf2 has been proven to have anti-inflammatory effects as well as an influence on mitochondrial activity and biogenesis, in addition to controlling the expression of antioxidant genes. This signal is only one of several defense mechanisms that our bodies might activate to slow the progression of neurodegenerative disorders.

This Special Issue will focus on potential novel treatment targets for inflammatory and neurodegenerative disorders. Its goal will be to identify antioxidant system activators that can be employed as medicinal agents. The Special Issue will include reviews, as well as original in vivo, in vitro, and preclinical research, that demonstrate the therapeutic impacts of novel molecules or natural compounds.

Dr. Tiziana Genovese
Dr. Daniela Impellizzeri
Dr. Rosalba Siracusa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidant systems
  • natural compounds
  • novel molecules
  • human health

Published Papers (1 paper)

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Review

17 pages, 1976 KiB  
Review
Oxidative Stress in Health and Disease
by
V. Prakash Reddy
Biomedicines 2023, 11(11), 2925; https://doi.org/10.3390/biomedicines11112925 - 29 Oct 2023
Viewed by 585
Abstract
Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), reactive nitrogen species (RNS), and other free radical species, contributes to the onset and progression of various diseases, including diabetes, obesity, diabetic nephropathy, diabetic neuropathy, and neurological diseases, such as [...] Read more.
Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), reactive nitrogen species (RNS), and other free radical species, contributes to the onset and progression of various diseases, including diabetes, obesity, diabetic nephropathy, diabetic neuropathy, and neurological diseases, such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD). Oxidative stress is also implicated in cardiovascular disease and cancer. Exacerbated oxidative stress leads to the accelerated formation of advanced glycation end products (AGEs), a complex mixture of crosslinked proteins and protein modifications. Relatively high levels of AGEs are generated in diabetes, obesity, AD, and other I neurological diseases. AGEs such as Ne-carboxymethyllysine (CML) serve as markers for disease progression. AGEs, through interaction with receptors for advanced glycation end products (RAGE), initiate a cascade of deleterious signaling events to form inflammatory cytokines, and thereby further exacerbate oxidative stress in a vicious cycle. AGE inhibitors, AGE breakers, and RAGE inhibitors are therefore potential therapeutic agents for multiple diseases, including diabetes and AD. The complexity of the AGEs and the lack of well-established mechanisms for AGE formation are largely responsible for the lack of effective therapeutics targeting oxidative stress and AGE-related diseases. This review addresses the role of oxidative stress in the pathogenesis of AGE-related chronic diseases, including diabetes and neurological disorders, and recent progress in the development of therapeutics based on antioxidants, AGE breakers and RAGE inhibitors. Furthermore, this review outlines therapeutic strategies based on single-atom nanozymes that attenuate oxidative stress through the sequestering of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Full article
(This article belongs to the Special Issue The Reactive Oxygen Species Signaling Pathway: Function and Regulation)
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