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Novel Players in Chemioresistance as New Targets for Cancer Treatment
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Novel Players in Chemioresistance as New Targets for Cancer Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3718

Special Issue Editors

Dr. Annapina Russo

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy
Interests: cancer; chemoresistance; nucleolar stress; extra-ribosomal function of ribosomal proteins; cell cycle
Special Issues, Collections and Topics in MDPI journals
Dr. Giulia Russo

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples Federico II, Naples, Italy
Interests: tumorigenesis; chemoresistance; nucleolar stress; apoptosis; ribosomal proteins

Special Issue Information

Dear Colleagues,

Cancer is one of the most common causes of death among adults. In the past decades cancer management was restricted to surgery, radiation therapy and chemotherapy either as single treatments or as combination therapy. However, the development of multidrug resistance continues to pose a significant challenge in cancer therapies. Therefore, a better understanding of the molecular basis underlying the mechanisms of drug resistance is necessary to  produce improved guidance to future cancer treatment. This special issue aims at  collect new discovery in the mechanisms of drug resistance, focusing on the therapeutic potential of targeting new pathways involved in chemoresistance.

The article may be either a full paper or a communication based on your own research in this area, or may be a focused review article on some aspect of the subject.

Dr. Annapina Russo
Dr. Giulia Russo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanisms of drug resistance
  • anticancer therapy
  • personalized therapies
  • combinatorial anticancer strategies
  • cancer
  • novel target drugs
  • molecular pathways underlying chemoresistance

Published Papers (1 paper)

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Review

17 pages, 2799 KiB  
Review
Physical Forces in Glioblastoma Migration: A Systematic Review
by Audrey Grossen, Kyle Smith, Nangorgo Coulibaly, Benjamin Arbuckle, Alexander Evans, Stefan Wilhelm, Kenneth Jones, Ian Dunn, Rheal Towner, Dee Wu, Young-Tae Kim and James Battiste
Int. J. Mol. Sci. 2022, 23(7), 4055; https://doi.org/10.3390/ijms23074055 - 06 Apr 2022
Cited by 7 | Viewed by 3122
Abstract
The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and [...] Read more.
The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and “sensing” capabilities. There is currently limited data on the physical forces in GBM—both relating to how they influence their environment and how their environment influences them. This review outlines the advances that have been made in the field. It is our hope that further investigation of the physical forces involved in GBM will highlight new therapeutic options and increase patient survival. A search of the PubMed database was conducted through to 23 March 2022 with the following search terms: (glioblastoma) AND (physical forces OR pressure OR shear forces OR compression OR tension OR torsion) AND (migration OR invasion). Our review yielded 11 external/applied/mechanical forces and 2 tumor microenvironment (TME) forces that affect the ability of GBM to locally migrate and invade. Both external forces and forces within the tumor microenvironment have been implicated in GBM migration, invasion, and treatment resistance. We endorse further research in this area to target the physical forces affecting the migration and invasion of GBM. Full article
(This article belongs to the Special Issue Novel Players in Chemioresistance as New Targets for Cancer Treatment)
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