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Valuable Bioactive Compounds from Prokaryotic and Eukaryotic Organisms
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Valuable Bioactive Compounds from Prokaryotic and Eukaryotic Organisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1331

Special Issue Editors

Dr. Blaženka Kos

E-Mail Website
Guest Editor
Laboratory for Antibiotic, Enzyme, Probiotic and Starter Culture Technologies, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia
Interests: lactic acid bacteria
Dr. Sanja Babić

E-Mail Website
Guest Editor
Laboratory for Aquaculture Biotechnology, Division of Materials Chemistry, Ruđer Bošković Institute, Zagreb, Croatia
Interests: antioxidant activity; (eco)toxicology; in vivo studies; model organisms; biological availability
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Stela Jokić

E-Mail Website
Guest Editor
Department of Process Engineering, Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
Interests: extraction; medicinal plants; supercritical carbon dioxide; industrial design; phenolic compounds; response surface methodology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The biological and chemical potential of prokaryotic and eukaryotic organisms represent a rich source of new products for the pharmaceutical, food, and cosmetic industries, among others. Therefore, in this Special Issue, we are consolidating research in the following areas:

  • the selection of prokaryotic and eukaryotic organisms with the potential to produce bioactive molecules,
  • the identification and characterization of specific metabolites,
  • the evaluation of biological potential using different model organisms and cell cultures,
  • in silico prediction, analytics, and modeling,
  • the development of sustainable biotechnological processes for the production of bioactive metabolites.

Dr. Blaženka Kos
Dr. Sanja Babić
Prof. Dr. Stela Jokić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • prokaryotic and eukaryotic organisms
  • specific metabolites
  • biological and chemical potential of prokaryotic and eukaryotic organisms

Published Papers (1 paper)

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Research

26 pages, 5084 KiB  
Article
An Integrated Comprehensive Peptidomics and In Silico Analysis of Bioactive Peptide-Rich Milk Fermented by Three Autochthonous Cocci Strains
by Martina Banić, Katarina Butorac, Nina Čuljak, Ana Butorac, Jasna Novak, Andreja Leboš Pavunc, Anamarija Rušanac, Željka Stanečić, Marija Lovrić, Jagoda Šušković and Blaženka Kos
Int. J. Mol. Sci. 2024, 25(4), 2431; https://doi.org/10.3390/ijms25042431 - 19 Feb 2024
Viewed by 964
Abstract
Bioactive peptides (BPs) are molecules of paramount importance with great potential for the development of functional foods, nutraceuticals or therapeutics for the prevention or treatment of various diseases. A functional BP-rich dairy product was produced by lyophilisation of bovine milk fermented by the [...] Read more.
Bioactive peptides (BPs) are molecules of paramount importance with great potential for the development of functional foods, nutraceuticals or therapeutics for the prevention or treatment of various diseases. A functional BP-rich dairy product was produced by lyophilisation of bovine milk fermented by the autochthonous strains Lactococcus lactis subsp. lactis ZGBP5-51, Enterococcus faecium ZGBP5-52 and Enterococcus faecalis ZGBP5-53 isolated from the same artisanal fresh cheese. The efficiency of the proteolytic system of the implemented strains in the production of BPs was confirmed by a combined high-throughput mass spectrometry (MS)-based peptidome profiling and an in silico approach. First, peptides released by microbial fermentation were identified via a non-targeted peptide analysis (NTA) comprising reversed-phase nano-liquid chromatography (RP nano-LC) coupled with matrix-assisted laser desorption/ionisation-time-of-flight/time-of-flight (MALDI-TOF/TOF) MS, and then quantified by targeted peptide analysis (TA) involving RP ultrahigh-performance LC (RP-UHPLC) coupled with triple-quadrupole MS (QQQ-MS). A combined database and literature search revealed that 10 of the 25 peptides identified in this work have bioactive properties described in the literature. Finally, by combining the output of MS-based peptidome profiling with in silico bioactivity prediction tools, three peptides (75QFLPYPYYAKPA86, 40VAPFPEVFGK49, 117ARHPHPHLSF126), whose bioactive properties have not been previously reported in the literature, were identified as potential BP candidates. Full article
(This article belongs to the Special Issue Valuable Bioactive Compounds from Prokaryotic and Eukaryotic Organisms)
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