Perspectives of Coumarins

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: closed (20 March 2020) | Viewed by 16476

Special Issue Editors

Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Interests: innovative green extraction methods: supercritical CO2 extraction, subritical water extraction, ultrasound- and microwave-assisted extraction of bioactive compounds from different raw materials, and biological investigation of the extracts. Production of high quality powders using spray drying technique and physical-chemical, biochemical, and pharmacological analyses of obtained extracts
Special Issues, Collections and Topics in MDPI journals
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 18, 31000 Osijek, Croatia
Interests: green chemistry; synthesis; heterocyclic compounds; coumarins; quinazolinones
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Coumarin (2-oxo-2H-chromene) is a heterocyclic compound bearing a benzene ring condensed with pyrone ring, and is assorted to the benzopyrone class of compounds. Coumarin and its derivatives have been proven to possess a wide range of biological activities, like antitumor, antifungal, antibacterial, anticoagulant, and anti-HIV activity. Natural coumarins are biosynthesized by plants as secondary metabolites during stress, water deprivation, wilting, pathogen attack, acting as the plants’ defense mechanism. Coumarin can be synthetically modified in order to change its biological activity, and there are many examples of synthetic coumarins with increased biological activity. Natural coumarins can be extracted from various coumarin-rich plants, like tonka beans, Melilotus officinalis, Galium odoratum, Hierochloe odorata, Lavandula angustifolia, etc. Some well-known coumarin-containing compounds with potent biological activity are aflatoxins, novobiocin, warfarin, and dicumarol.

This Special Issue scope is to bring together eminent researchers presenting their investigations of coumarin synthesis, extraction, biological activity, and potential application.

Prof. Stela Jokić
Prof. Maja Molnar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Coumarin
  • synthesis of coumarin derivatives
  • extraction of coumarins
  • coumarin-containing plants
  • biological activity of coumarin derivatives

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

35 pages, 26304 KiB  
Review
Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials
by Melita Lončarić, Dajana Gašo-Sokač, Stela Jokić and Maja Molnar
Biomolecules 2020, 10(1), 151; https://doi.org/10.3390/biom10010151 - 16 Jan 2020
Cited by 95 | Viewed by 15685
Abstract
The study of coumarin dates back to 1820 when coumarin was first extracted from tonka bean by Vogel. Compounds containing coumarin backbone are a very important group of compounds due to their usage in pharmacy and medicine. Properties and biological activities of coumarin [...] Read more.
The study of coumarin dates back to 1820 when coumarin was first extracted from tonka bean by Vogel. Compounds containing coumarin backbone are a very important group of compounds due to their usage in pharmacy and medicine. Properties and biological activities of coumarin derivatives have a significant role in the development of new drugs. Therefore, many different methods and techniques are developed in order to synthesize coumarin derivatives. Coumarin derivatives could be obtained from different starting materials with various methods but with big differences in yield. This review summarized various methods, techniques and reaction conditions for synthesis of coumarins from different compounds such as aldehydes, phenols, ketones and carboxylic acids. Full article
(This article belongs to the Special Issue Perspectives of Coumarins)
Show Figures

Figure 1

Back to TopTop