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Small Molecules Containing Sulfur, Selenium, or Tellurium as Bioactive Compounds 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 2252

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain
Interests: selenium; cancer; trypanosome; NSAIDs; organic synthesis; molecular biology; chemical sciences
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Special Issue Information

Dear Colleagues,

Substantial evidence suggests that small organic molecules decorated with sulfur, selenium, or tellurium (organochalcogens) have a plethora of effects on different diseases, including cancer, Alzheimer’s, and infectious and parasitic diseases. This Special Issue will gather the latest advances in the preclinical development of these organochalcogen derivatives. Thus, this Special Issue will collect strong in vitro and in vivo data regarding the molecular biology of these organochalcogens. Additionally, research articles could contain synthesis and characterization of new organochalcogen derivatives and the development of new carriers, although it is not the main aim of this Special Issue. To sum up, this Special Issue will contribute to the preclinical development of organochalcogens, which have demonstrated to date unique and unexpected features compared with the related non-organochalcogen analogs.

Dr. Daniel Plano Amatriain
Guest Editor

Manuscript Submission Information

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Keywords

  • sulfur
  • selenium
  • tellurium
  • organochalcogen
  • cancer
  • Alzheimer’s
  • parasitic diseases
  • infectious diseases

Published Papers (1 paper)

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Research

20 pages, 17478 KiB  
Article
κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice
by Kai Wang, Ling Qin, Junhan Cao, Liping Zhang, Ming Liu, Changfeng Qu and Jinlai Miao
Int. J. Mol. Sci. 2023, 24(5), 4672; https://doi.org/10.3390/ijms24054672 - 28 Feb 2023
Cited by 6 | Viewed by 1910
Abstract
κ-Selenocarrageenan (KSC) is an organic selenium (Se) polysaccharide. There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs). This study explored an enzyme, κ-selenocarrageenase (SeCar), from deep-sea bacteria and produced heterologously in Escherichia coli, which degraded [...] Read more.
κ-Selenocarrageenan (KSC) is an organic selenium (Se) polysaccharide. There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs). This study explored an enzyme, κ-selenocarrageenase (SeCar), from deep-sea bacteria and produced heterologously in Escherichia coli, which degraded KSC to KSCOs. Chemical and spectroscopic analyses demonstrated that purified KSCOs in hydrolysates were composed mainly of selenium-galactobiose. Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD). This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice. The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10). Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia. These findings proved that KSCOs obtained by enzymatic degradation could be utilized to prevent or treat UC. Full article
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