Advances in Tumor Microenvironment and Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2270
Special Issue Editor
Interests: tumor microenvironment; obesity; cell signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The tumor microenvironment has profound effects on cancer development, progression, and treatment response. Cancer cells coexist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the tumor microenvironment. Additionally, the biochemical and biophysical properties of the tumor microenvironment are different from those of normal tissue. Several features of the tumor microenvironment have been identified, including hypoxia, acidosis, high interstitial fluid pressure, and increased extracellular matrix (ECM) stiffness. The metabolism of cancer cells is reprogrammed from that of normal cells. The glycolytic metabolism of cacti produces lactic acid, which, after being excreted by cancer cells, can acidify the tumor microenvironment. Additionally, tumor-associated hypoxia can lead to rapid cancer growth, and defective vascular perfusion can further increase cellular glycolysis as well as lactate production and accumulation in the tumor microenvironment. Cancer cell metabolism is being exploited as a target for cancer therapy. This Special Issue will address several aspects of the tumor microenvironment and metabolism. Despite considerable research progress, the complex interplay between cancer cells, metabolism, and the tumor microenvironment is still not fully understood, and we would like to provide open source sharing that may enhance our understanding.
Dr. Ju-Ock Nam
Guest Editor
Manuscript Submission Information
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Keywords
- vasculature
- hypoxia
- carcinoma-associated fibroblast
- extracellular matrix protein
- immune cells
- tumor-cell mitochondria
- glycolysis
- metabolic reprogramming
- lactic acidosis
- cancer chachexia
