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Prevention and Treatment of Metabolic Diseases Using Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 708

Special Issue Editor

Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: tumor microenvironment; obesity; cell signaling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases refer to those caused by abnormal metabolic processes, and they mainly occurs in obese patients or people who are older, lead a sedentary lifestyle, and have insulin resistance. In all cases, disorders of metabolic regulation cause impairment of normal cell function and worsen the disease.

Metabolic disorders caused by obesity and aging cause damage at the cellular level, including mitochondrial dysfunction, oxidative stress, and endoplasmic reticulum stress. Damage to metabolic tissues such as adipose tissue and muscle tissue caused by metabolic disorders leads to impaired energy storage and consumption, gradually worsening the disease and causing secondary complications such as diabetes. As a treatment strategy for metabolic diseases, the expression, activity, and binding of specific proteins can be regulated through treatment with natural products at the molecular level. Additionally, the properties of natural products, such as antioxidant ability, can be utilized.

This Special Issue will focus on modulating molecular mechanisms using natural products as a strategy for preventing and treating metabolic diseases. We cordially invite you to contribute to this field of knowledge by submitting your latest findings, reviews, or research papers.

Dr. Ju-Ock Nam
Guest Editor

Manuscript Submission Information

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Keywords

  • metabolic diseases
  • metabolic disorders
  • natural products
  • specific proteins
  • antioxidant ability

Published Papers (1 paper)

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Research

16 pages, 3516 KiB  
Article
Anti-Obesity and Anti-Diabetic Effects of Ostericum koreanum (Ganghwal) Extract
by Eunbi Lee and Ju-Ock Nam
Int. J. Mol. Sci. 2024, 25(9), 4908; https://doi.org/10.3390/ijms25094908 - 30 Apr 2024
Viewed by 470
Abstract
Ganghwal” is a widely used herbal medicine in Republic of Korea, but it has not been reported as a treatment strategy for obesity and diabetes within adipocytes. In this study, we determined that Ostericum koreanum extract (OKE) exerts an anti-obesity effect [...] Read more.
Ganghwal” is a widely used herbal medicine in Republic of Korea, but it has not been reported as a treatment strategy for obesity and diabetes within adipocytes. In this study, we determined that Ostericum koreanum extract (OKE) exerts an anti-obesity effect by inhibiting adipogenesis and an anti-diabetic effect by increasing the expression of genes related to glucose uptake in adipocytes and inhibiting α-glucosidase activity. 3T3-L1 preadipocytes were differentiated for 8 days in methylisobutylxanthine, dexamethasone, and insulin medium, and the effect of OKE was confirmed by the addition of 50 and 100 µg/mL of OKE during the differentiation process. This resulted in a reduction in lipid accumulation and the expression of PPARγ (Peroxisome proliferator-activated receptor γ) and C/EBPα (CCAAT enhancer binding protein α). Significant activation of AMPK (AMP-activated protein kinase), increased expression of GLUT4 (Glucose Transporter Type 4), and inhibition of α-glucosidase activity were also observed. These findings provide the basis for the anti-obesity and anti-diabetic effects of OKE. In addition, OKE has a significant antioxidant effect. This study presents OKE as a potential natural product-derived material for the treatment of patients with metabolic diseases such as obesity- and obesity-induced diabetes. Full article
(This article belongs to the Special Issue Prevention and Treatment of Metabolic Diseases Using Natural Products)
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