Mitochondrial Dysfunction and Oxidative Stress in Parkinson’s Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 1141
Special Issue Editor
Interests: mitochondrial dysfunction; oxidative stress; coenzyme Q10
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Parkinson’s disease (PD) is one of the most common progressive neurodegenerative disorders of which the aetiology is still largely unknown. Although, mitochondrial dysfunction and oxidative stress (OS) are thought to be important pathophysiological factors in the disease progression.
Mitochondrial dysfunction centred at complex I of the mitochondrial respiratory chain (MRC) has been well documented in the substantia nigra of patients with PD; although the cause of this impairment has yet to be fully elucidated, it may be the result of OS-induced oxidative damage to the MRC and mitochondrial DNA. Interestingly, mutations in several genes associated with the familial forms of PD can also impact mitochondrial function, although whether this results in a direct impairment of MRC enzyme activity has yet to be confirmed. OS occurs when cellular antioxidants are overwhelmed by a surplus generation of reactive oxygen species (ROS), which in PD, is possibly caused by a number of factors including the reactive metabolites of dopamine and alterations in the level of iron as well as neuro-inflammation and MRC dysfunction in the substantia nigra and mid-brain regions. In addition, perturbations in glutathione metabolism and the pentose phosphate pathway may also contribute to the OS associated with PD.
This Special Issue aims to highlight appropriate antioxidant therapeutic strategies that ameliorate OS in disease and target the mitochondria. This Special Issue will also focus on suitable low-invasive methods to assess evidence of OS in patients and their application to disease monitoring.
Dr. Iain P. Hargreaves
Guest Editor
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Keywords
- Parkinson’s disease (PD)
- reactive oxygen species (ROS)
- oxidative stress (OS)
- mitochondrial respiratory chain (MRC)
- mitochondrial dysfunction
- glutathione, pentose phosphate pathway
