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Oxidative Stress in Metabolic and Non-metabolic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 319

Special Issue Editor

Special Issue Information

Dear Colleagues,

Mitochondria are a major source of reactive oxygen species (ROS) generation within the cell. Electron leakage from complexes I and III of the mitochondrial respiratory chain (MRC) causes the partial reduction of molecular oxygen to the superoxide, which is then dismutated to hydrogen peroxidase by superoxide dismutase. Both superoxide and hydrogen peroxide are considered mitochondrial ROS. Under physiological conditions, ROS act as potential secondary messengers which could be used to specifically modulate distinct cellular pathways, including the innate immunity signalling cascade. However, once the level of ROS production exceeds the scavenging capacity of the cellular antioxidant defence system, a condition known as oxidative stress (OS) arises, which can induce a secondary mitochondrial dysfunction as opposed to a primary mitochondrial dysfunction which is an inherited genetic disorder. OS can induce DNA mutations, impair MRC activity, alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial internal defence mechanisms leading to an impaired mitochondrial function and contributing to disease pathophysiology. OS and mitochondrial dysfunction have been implicated in the progression of a number of diseases, including the neurodegenerative disorders of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, metabolic diseases such as MRC disorders and lysosomal storage disorders, diabetes, cardiovascular diseases and cancer. The use of appropriate antioxidant adjunct therapies may be particularly important in the treatment of diseases associated with mitochondrial dysfunction and OS, although treatment protocols have yet to be fully established or standardised. Since mitochondria are a major contributor to cellular OS in the disease state, antioxidant strategies targeting this organelle may offer particular therapeutic potential. However, an excessive administration of antioxidants may inhibit ROS-dependent signalling pathways and prevent the induction of endogenous antioxidant defence systems. In order to detect evidence of OS in patients and to ensure appropriate levels of antioxidant therapy, non-invasive assessments of plasma or white blood cell antioxidant status or the stable end products of lipid, DNA or protein oxidation may be appropriate, although, as yet, these procedures may only be available at specialist centres or on an ad hoc basis. Therefore, it is particularly important to engender some consensus with the aim of establishing a unified approach to monitor evidence of OS in patients, together with the development of appropriate therapeutic strategies that can target OS in disease.

This Special Issue aims to highlight appropriate antioxidant therapeutic strategies to mitigate OS in disease and target the mitochondria. This Special Issue will also focus on suitable low-invasive methods to assess evidence of OS in patients and their application to disease monitoring.

Dr. Iain P. Hargreaves
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mitochondria
  • reactive oxygen species (ROS)
  • oxidative stress
  • mitochondrial respiratory chain (MRC)
  • mitochondrial dysfunction
  • neurodegenerative disorders
  • metabolic diseases

Published Papers

There is no accepted submissions to this special issue at this moment.
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