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Latest Research on Brain Science: Based on Neurogenomics
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Latest Research on Brain Science: Based on Neurogenomics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2781

Special Issue Editor

Dr. Candace R Lewis

E-Mail Website
Guest Editor
1. Department of Psychology, School of Life Sciences, Arizona State Universisty, Phoenix, AZ 85004, USA
2. Neurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA
Interests: fMRI/MRI; epigenetics; transcriptomics; genomics; brain structure/function; mental health; behavioral health; psychiatric; trauma/stress; exposure

Special Issue Information

Dear Colleagues,

Neurogenomics is the interface between neurobiology and genome sciences, and it can elucidate how genomic processes contribute to brain evolution, development, structure and function. Neurogenomics can be used to study the nervous system in the context of the underlying regulatory and transcriptional networks. Neurogenomics researchers employ genetic strategies, including investigations of the genome sequence and products (transcriptomes and proteomes), to identify genes involved in the nervous system. Additionally, animal methods can be employed to manipulate genomic processes.

The aim of this Special Issue is to highlight research that uses a combination of genomic and brain measurements to reveal biological pathways from genetic and genomic variation to brain disease. This will enable us to understand the infinitely complex etiologies of neurodevelopmental, psychiatric, and neurodegenerative disorders, improve the ability to diagnose brain diseases before they occur, and facilitate the development of novel therapeutic targets. Due to the scope of IJMS, purely clinical studies are not suitable. However, clinical or pure model submissions with biomolecular experiments are welcomed.

Dr. Candace R Lewis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

15 pages, 5177 KiB  
Article
Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone
by Momoko Fukuda, Yuki Fujita, Yuko Hino, Mitsuyoshi Nakao, Katsuhiko Shirahige and Toshihide Yamashita
Int. J. Mol. Sci. 2024, 25(5), 2540; https://doi.org/10.3390/ijms25052540 - 22 Feb 2024
Viewed by 787
Abstract
In the adult mammalian brain, neurons are produced from neural stem cells (NSCs) residing in two niches—the subventricular zone (SVZ), which forms the lining of the lateral ventricles, and the subgranular zone in the hippocampus. Epigenetic mechanisms contribute to maintaining distinct cell fates [...] Read more.
In the adult mammalian brain, neurons are produced from neural stem cells (NSCs) residing in two niches—the subventricular zone (SVZ), which forms the lining of the lateral ventricles, and the subgranular zone in the hippocampus. Epigenetic mechanisms contribute to maintaining distinct cell fates by suppressing gene expression that is required for deciding alternate cell fates. Several histone deacetylase (HDAC) inhibitors can affect adult neurogenesis in vivo. However, data regarding the role of specific HDACs in cell fate decisions remain limited. Herein, we demonstrate that HDAC8 participates in the regulation of the proliferation and differentiation of NSCs/neural progenitor cells (NPCs) in the adult mouse SVZ. Specific knockout of Hdac8 in NSCs/NPCs inhibited proliferation and neural differentiation. Treatment with the selective HDAC8 inhibitor PCI-34051 reduced the neurosphere size in cultures from the SVZ of adult mice. Further transcriptional datasets revealed that HDAC8 inhibition in adult SVZ cells disturbs biological processes, transcription factor networks, and key regulatory pathways. HDAC8 inhibition in adult SVZ neurospheres upregulated the cytokine-mediated signaling and downregulated the cell cycle pathway. In conclusion, HDAC8 participates in the regulation of in vivo proliferation and differentiation of NSCs/NPCs in the adult SVZ, which provides insights into the underlying molecular mechanisms. Full article
(This article belongs to the Special Issue Latest Research on Brain Science: Based on Neurogenomics)
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11 pages, 1542 KiB  
Article
APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory
by Samantha A. Harker, Lamees Al-Hassan, Matthew J. Huentelman, B. Blair Braden and Candace R. Lewis
Int. J. Mol. Sci. 2023, 24(21), 15988; https://doi.org/10.3390/ijms242115988 - 05 Nov 2023
Cited by 1 | Viewed by 1442
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence suggests that autistic adults are more likely to develop Alzheimer’s disease (Alz) and other dementias compared to neurotypical (NT) adults. The ε4-allele of the Apolipoprotein E (APOE) gene is the [...] Read more.
Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence suggests that autistic adults are more likely to develop Alzheimer’s disease (Alz) and other dementias compared to neurotypical (NT) adults. The ε4-allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alz and negatively impacts cognition in middle-aged and older (MA+) adults. This study aimed to determine the impact of the APOE ε4-allele on verbal learning and memory in MA+ autistic adults (ages 40–71 years) compared to matched NT adults. Using the Auditory Verbal Learning Test (AVLT), we found that ε4 carriers performed worse on short-term memory and verbal learning across diagnosis groups, but there was no interaction with diagnosis. In exploratory analyses within sex and diagnosis groups, only autistic men carrying APOE ε4 showed worse verbal learning (p = 0.02), compared to autistic men who were not carriers. Finally, the APOE ε4-allele did not significantly affect long-term memory in this sample. These findings replicate previous work indicating that the APOE ε4-allele negatively impacts short-term memory and verbal learning in MA+ adults and presents new preliminary findings that MA+ autistic men may be vulnerable to the effects of APOE ε4 on verbal learning. Future work with a larger sample is needed to determine if autistic women may also be vulnerable. Full article
(This article belongs to the Special Issue Latest Research on Brain Science: Based on Neurogenomics)
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