Modifications of Molecular Structure and Interactions in Epigenome 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 1370
Special Issue Editors
Interests: theoretical and computer chemistry; malaria drug development
Special Issues, Collections and Topics in MDPI journals
Interests: pharmacoinformatics; chemical biology; structural biochemistry; bioinformatics; bioanalysis; protein; peptide; signaling; epigenetics; Alzheimer's disease; HIV
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Beyond the regulatory mechanisms of classical genetics, epigenetics offers new answers to fundamental questions of life in regard to fertility, embryo development, and aging. The molecular machinery of epigenetic regulation has been correlated with various aspects of environmental pollution, psychological stress, physical activity, and nutrition. Public health issues, such as tobacco smoking or alcoholism, have also been investigated in the context of epigenetics. In the past few decades, the identification of epigenetic drug targets has become an emerging field. Beyond the classical genetic background of cancer, epigenetic abnormalities have been detected during the initiation and propagation of the disease. The pathophysiology of autoimmune and inflammatory diseases has also been associated with epigenetic alterations in immune and other cells.
Epigenetic regulation involves heritable changes in gene expression that occur independent of changes in the primary DNA sequence. Such changes in gene expression are coupled to the chromatin structure. Modifications of its components, such as DNA methylation, covalent histone modifications, nucleosome positioning, histone variants, and miRNAs, add up to combinatorial patterns collectively termed as the epigenome. The regulatory machinery also involves numerous enzymes and other proteins interacting with chromatin components. The understanding and precise description of such molecular interactions is key to the mapping of the epigenome and to the design of new molecules interfering with epigenetic diseases. The present Special Issue welcomes manuscripts on molecular interactions of epigenetic regulation, including new methodological approaches and applications of established techniques.
Dr. Uko Maran
Dr. Csaba Hetényi
Guest Editors
Manuscript Submission Information
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Keywords
- molecular epigenetics
- chemical epigenetics
- cryo-electron microscopy
- crystallography
- NMR
- structural bioinformatics
- cheminformatics
- molecular modeling
- molecular dynamics
- docking target selection
- target validation
- post-translational modification
- PTM
- covalent modification
- methylation
- acetylation
- histone code
- reader
- writer
- transferase
- PHD finger
- bromodomain
- free energy
- binding
- isothermal titration calorimetry
- surface plasmon resonance spectroscopy
- peptide
