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Special Issue "Application of Nanotechnology in Regenerative Medicine"

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Dear Colleagues,

According to Greenwood and co-workers “regenerative medicine is an emerging interdisciplinary field of research and clinical applications focused on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function resulting from any cause, including congenital defects, disease, trauma and aging. It uses a combination of several technological approaches that moves it beyond traditional transplantation and replacement therapies.” Nanotechnology ranks high among these approaches, and especially in the last two decades, its application in regenerative medicine has enormously advanced and proved to be crucial for the development of new materials able to restore and support damaged tissues and organs. Through nanotechnology, it is now possible to design engineered nanostructures able to mimic tissue-specific bio-environments. Among them, engineered nanoscaffolds of a particular biochemical can be enriched, and the mechanical and electrical properties able to improve cell adhesion, proliferation and differentiation. Moreover, biomolecule-loaded nanostructures may control the sustained release of active compounds, thus improving treatment effectiveness and patient compliance. The application of nanoconstructs can often help avoid surgery, while accelerating healing, limiting side effects and overcoming the problem of organ donor shortage.

In this scenario, the present Special Issue is aimed at illustrating the great contribution of nanotechnology in regenerative medicine, presenting novel approaches and tools to support tissue and organ repair.

We invite researchers of all the relevant fields (chemistry, physics, biology, biotechnology, medicine, pharmacology, engineering) to present their results and commentaries by contributing original research articles or review papers.

Dr. Flavia Carton
Prof. Manuela Malatesta
Guest Editors

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Keywords

nanotechnology
regenerative medicine
nanomaterials
biomanufacturing
nanoscaffolds
tissue engineering
drug delivery
three-dimensional printing

Published Papers (2 papers)

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Review

39 pages, 2667 KiB

Open AccessReview

Biomedical Approach of Nanotechnology and Biological Risks: A Mini-Review

Debora F. Silva

Ailime L. P. Melo

Ana F. C. Uchôa

Graziela M. A. Pereira

Alisson E. F. Alves

Maria C. Vasconcellos

Francisco H. Xavier-Júnior

and

Marcele F. Passos

Int. J. Mol. Sci. 2023, 24(23), 16719; https://doi.org/10.3390/ijms242316719 - 24 Nov 2023

Viewed by 335

Abstract

Nanotechnology has played a prominent role in biomedical engineering, offering innovative approaches to numerous treatments. Notable advances have been observed in the development of medical devices, contributing to the advancement of modern medicine. This article briefly discusses key applications of nanotechnology in tissue engineering, controlled drug release systems, biosensors and monitoring, and imaging and diagnosis. The particular emphasis on this theme will result in a better understanding, selection, and technical approach to nanomaterials for biomedical purposes, including biological risks, security, and biocompatibility criteria. Full article

(This article belongs to the Special Issue Application of Nanotechnology in Regenerative Medicine)

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22 pages, 1930 KiB

Open AccessReview

Effectiveness of Cerium Oxide Nanoparticles in Non-Alcoholic Fatty Liver Disease Evolution Using In Vivo and In Vitro Studies: A Systematic Review

and

Int. J. Mol. Sci. 2023, 24(21), 15728; https://doi.org/10.3390/ijms242115728 - 29 Oct 2023

Viewed by 447

Abstract

Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of liver abnormalities, from benign steatosis to nonalcoholic steatohepatitis (NASH). Because of their antioxidant capabilities, CeNPs have sparked a lot of interest in biological applications. This review evaluated the effectiveness of CeNPs in NAFLD evolution through in vivo and in vitro studies. Databases such as MEDLINE, EMBASE, Scopus, and Web of Science were looked for studies published between 2012 and June 2023. Quality was evaluated using PRISMA guidelines. We looked at a total of nine primary studies in English carried out using healthy participants or HepG2 or LX2 cells. Quantitative data such as blood chemical markers, lipid peroxidation, and oxidative status were obtained from the studies. Our findings indicate that NPs are a possible option to make medications safer and more effective. In fact, CeNPs have been demonstrated to decrease total saturated fatty acids and foam cell production (steatosis), reactive oxygen species production and TNF-α (necrosis), and vacuolization in hepatic tissue when used to treat NAFLD. Thus, CeNP treatment may be considered promising for liver illnesses. However, limitations such as the variation in durations between studies and the utilization of diverse models to elucidate the etiology of NAFLD must be considered. Future studies must include standardized NAFLD models. Full article

(This article belongs to the Special Issue Application of Nanotechnology in Regenerative Medicine)

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Special Issue "Application of Nanotechnology in Regenerative Medicine"

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