Modulation of Microbiota-Gut-Brain Axis in the Disorders of Brain and Mind
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 20513
Special Issue Editors
Interests: neurological diseases; pathophysiology; therapeutics; animal models; molecular mechanisms; drug development; mitochondria; biomarker; posttranslational modification; transcription factor; gut-brain axis; Huntington’s disease; Parkinson’s disease; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals
Interests: antimicrobial packaging; antimicrobial activity; edible films; biofilms; bioactive compounds
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Special Issue Information
Dear Colleagues,
Despite its conceptualization in the 18th century, the microbiota-gut-brain research went into a temporary hiatus for a while and was largely sidelined until it was thrust back into action with the realization of the “second brain” theory in the late 1990s. Presently, the bidirectional communications that span through the central nervous system (brain and spinal cord), the autonomic nervous system, the enteric nervous system and the hypothalamic-pituitary-adrenal axis through neuroimmune, neuroendocrine, and direct neural pathways such as the vagus nerve, are often referred to as the microbiota-gut-brain axis. Aging, high fat/low fiber diet, life-style related factors, such as stress, obesity, sedentary living etc. as well as certain infections alter the normal balance of gut microbiota resulting in dysbiosis. Dysbiosis is further thought to increase the permeability of intestinal epithelial barrier, promoting invasion of different bacteria, viruses, and their neuroactive products that support neuroinflammatory reactions in the brain, produce blood-brain barrier dysfunction and induce systemic inflammation. More recently, gut microbiota dysbiosis is considered to be a contributing factor in the disorders of brain and mind, namely, neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), and psychiatric disorders including schizophrenia, bipolar disorder, autism, dementia, depression and anxiety. The modulation of gut microbiota through personalized diet, oral bacteriotherapy including prebiotics, medicinal herbs, probiotics, and synbiotics have opened new vistas for exploration of potential therapeutic opportunities. With our special issue, we hope to bring to fore the recent progress made in the elucidation of mechanisms of this ‘central connection’ and targeted therapeutic modulation of the microbiota-gut-brain axis in the context of neurodegenerative diseases and psychiatric disorders.
Topics of this special issue include, but are not limited to:
- Modulation of gut-brain axis in neurodegeneration: mechanisms and potential therapeutic interventions;
- Contribution of dysbiosis to the development of Alzheimer’s disease pathologies and cognitive impairment;
- Gut microbiome and Parkinson’s disease;
- Role of microbiota-gut-brain axis in management of mental health disorders such as depression, anxiety, bipolar disorder, post-traumatic stress disorder (PTSD), schizophrenia;
- Therapeutic benefits of a healthy gut to reduce systemic inflammation for a healthy brain and mind.
Dr. Ashu Johri
Prof. Dr. Dan Cristian Vodnar
Guest Editors
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Keywords
- neurodegeneration
- Parkinson’s disease
- Alzheimer’s disease
- mood disorders
- psychiatric disorders
- intestinal flora
- dysbiosis
- gut-brain axis
- therapeutics