Advanced Biochemical Research: Transcription in Cancer Initiation and Progression
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 9236
Special Issue Editor
Interests: transcription; epigenetics; PARP1; SWI/SNF; EP300; differentiation; cancerogenesis; chromatin; transcription factors; transcription co-factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The transformation of normal healthy cells into cancer cells is a complex multistep process, mostly associated with the de-differentiation of specialized cells, the re-entrance of G0/G1-arrested cells to mitotic divisions, the ability to spread and invade tissues, as well as immortality. Although the initiation of carcinogenesis is linked with mutations and a loss of genomic stability, the following promotion and progression steps require alteration also in other “-omics”. Transcriptional reprogramming adapts the proteome of the transforming cell to new phenotypes by facilitating a gradual decrease in the expression of cell type or highly specific tissue genes, and by enhancing the expression of factors that promote proliferation, migration, and metastases.
Our issue is dedicated to the elucidation of the essential transcription-relevant events that contribute to carcinogenesis, and to the identification of emerging hubs where gene transcription and malignancy interact with each other. Therefore, we invite submissions that cover genome-wide as well as gene-specific chromatin remodeling that accompanies all stages of tumor development. We aim to identify transcription factors, co-factors, nucleosome readers, writers, and erasers that drive cell transformation. Our Specials Issue also aims to publish papers dealing with the molecular basis of oncogene expression, the repression of tumor suppressors, the role of cell cycle progression, and E2F-dependent gene transcription in gaining the cancer phenotype. Likewise, we are particularly interested in all aspects dealing with transcription of factors, which make malignant cells resistant to anti-cancer approaches.
Dr. Agnieszka Zdzislawa Robaszkiewicz
Guest Editor
Manuscript Submission Information
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Keywords
- cancer
- transcription
- transcription factors and co-factors
- chromatin remodeling
- epigenetic modification
- oncogenes
- suppressors
- cell cycle
- E2F-dependent gene transcription
- tumor resistance
- signaling
