Anti-cancer Drug Chemoresistance and New Chemosensitization Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (10 December 2023) | Viewed by 6202
Special Issue Editors
Interests: chemoresistance; angiogenesis; metastatic cells; stem cells; cell death; drug efflux; metastatic drug target; endothelial cell progenitor; breast cancer
2. Hospital Avicenne, Université Sorbonne Paris Nord, Villetaneuse, France
Interests: oncology; PDX; stem cells; chemoresistance; nanotechnologies; breast cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although many cancer cells are sensitive to chemotherapy, cancer progression is concomitant with the acquisition of drug resistance. Chemoresistance is a complex phenomenon involving both intracellular and extracellular mechanisms, and requires further study. Among the intracellular pathways, drug inactivation or metabolism, drug efflux, drug target alteration, DNA damage or epigenetic changes, cell death inhibition and autophagy processes, the exosome and the epithelial–mesenchymal transition (EMT) are still under investigation (Housman et al., 2014). Tumor heterogeneity involves specific cells resistant to chemotherapy, such as stem cells or metastatic resistant cells (Nunes et al. 2018). In addition, resistance through the extracellular matrix (fibroblast and endothelial cells) could represent a method of studying resistance in tumors (Staussman,2012). Indeed, the use of anti-angiogenic drugs to target resistance has been demonstrated in the acquisition of resistance through endothelial cell plasticity, as well as endothelial cell progenitors, in the same manner as that for cancer cells (Bousquet el al. 2019). Understanding the molecular mechanisms involved in these pathways represents a big challenge in overcoming resistance.
More recently, the role of exposure to low doses of environmental pollutants in cancer initiation, as well as in cancer progression, has been raised by several studies, which suggest that these chemicals could promote drug resistance (Koual et al. 2020). Studying the molecular mechanisms linked to pollutant exposure could offer an avenue of development for new chemosensitization strategies.
In this Special Issue, we welcome submissions that will contribute to our understanding of the molecular mechanisms implicated in drug resistance acquisition, in particular, those implicating extracellular pathways (stem cells, angiogenesis, and EMT), tumor heterogeneity, and the exposome.
Prof. Dr. Mélanie Di Benedetto
Dr. Guilhem Bousquet
Guest Editors
Manuscript Submission Information
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Keywords
- chemoresistance
- angiogenesis
- stem cells
- autophagy
- exposome
- tumor heterogeneity
