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Molecular Research on Skeletal Muscle Biology
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Molecular Research on Skeletal Muscle Biology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1772

Special Issue Editor

Dr. Atsushi Asakura

E-Mail Website
Guest Editor
Paul & Sheila Wellstone Muscular Dystrophy Center, Department of Neurology, Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Interests: muscular dystrophy; satellite cell; gene therapy; exon skipping; muscle regeneration; iPSC; dystrophin; skeletal muscle
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skeletal muscle biology is a fascinating world that belongs to the fields of muscles, aging, kinesiology, and regenerative medicine. Biological studies on skeletal muscle underlie a wide range of physiological processes, such as the development and normal functioning of skeletal muscles, and may participate in or even cause progressive changes in pathophysiology. Skeletal muscle atrophy and dysfunction are common features of many disorders. Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and an X-linked progressive muscle-wasting disease.

Our goals include attempting to understand the molecular mechanisms of skeletal muscle development and to develop novel therapeutic methods for muscular dystrophy.

Dr. Atsushi Asakura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skeletal muscle
  • muscular dystrophy
  • satellite cell
  • muscle regeneration
  • myofibrosis
  • exercise

Published Papers (2 papers)

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Research

14 pages, 4465 KiB  
Article
DIA-Based Proteomic Analysis Reveals MYOZ2 as a Key Protein Affecting Muscle Growth and Development in Hybrid Sheep
by Dan Zhang, Yaojing Yue, Chao Yuan, Xuejiao An, Tingting Guo, Bowen Chen, Jianbin Liu and Zengkui Lu
Int. J. Mol. Sci. 2024, 25(5), 2975; https://doi.org/10.3390/ijms25052975 - 04 Mar 2024
Viewed by 606
Abstract
Hybridization of livestock can be used to improve varieties, and different hybrid combinations produce unique breeding effects. In this study, male Southdown and Suffolk sheep were selected to hybridize with female Hu sheep to explore the effects of male parentage on muscle growth [...] Read more.
Hybridization of livestock can be used to improve varieties, and different hybrid combinations produce unique breeding effects. In this study, male Southdown and Suffolk sheep were selected to hybridize with female Hu sheep to explore the effects of male parentage on muscle growth and the development of offspring. Using data-independent acquisition technology, we identified 119, 187, and 26 differentially abundant proteins (DAPs) between Hu × Hu (HH) versus Southdown × Hu (NH), HH versus Suffolk × Hu (SH), and NH versus SH crosses. Two DAPs, MYOZ2 and MYOM3, were common to the three hybrid groups and were mainly enriched in muscle growth and development-related pathways. At the myoblast proliferation stage, MYOZ2 expression decreased cell viability and inhibited proliferation. At the myoblast differentiation stage, MYOZ2 expression promoted myoblast fusion and enhanced the level of cell fusion. These findings provide new insights into the key proteins and metabolic pathways involved in the effect of male parentage on muscle growth and the development of hybrid offspring in sheep. Full article
(This article belongs to the Special Issue Molecular Research on Skeletal Muscle Biology)
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11 pages, 2194 KiB  
Article
α-Pinene, a Main Component of Pinus Essential Oils, Enhances the Expression of Insulin-Sensitive Glucose Transporter Type 4 in Murine Skeletal Muscle Cells
by Giordana Feriotto, Federico Tagliati, Valentina Costa, Marcello Monesi, Claudio Tabolacci, Simone Beninati and Carlo Mischiati
Int. J. Mol. Sci. 2024, 25(2), 1252; https://doi.org/10.3390/ijms25021252 - 19 Jan 2024
Viewed by 740
Abstract
Glucose transporter-4 (GLUT4) represents the major glucose transporter isoform responsible for glucose uptake into insulin-sensitive cells, primarily in skeletal muscle and adipose tissues. In insulin-resistant conditions, such as type 2 diabetes mellitus, GLUT4 expression and/or translocation to the cell plasma membrane is reduced, [...] Read more.
Glucose transporter-4 (GLUT4) represents the major glucose transporter isoform responsible for glucose uptake into insulin-sensitive cells, primarily in skeletal muscle and adipose tissues. In insulin-resistant conditions, such as type 2 diabetes mellitus, GLUT4 expression and/or translocation to the cell plasma membrane is reduced, compromising cell energy metabolism. Therefore, the use of synthetic or naturally occurring molecules able to stimulate GLUT4 expression represents a good tool for alternative treatments of insulin resistance. The present study aimed to investigate the effects of essential oils (EOs) derived from Pinus spp. (P. nigra and P. radiata) and of their main terpenoid constituents (α- and β-pinene) on the expression/translocation of GLUT4 in myoblast C2C12 murine cells. For this purpose, the chemical profiles of the EOs were first analyzed through gas chromatography–mass spectrometry (GC-MS). Cell viability was assessed by MTT assay, and GLUT4 expression/translocation was evaluated through RT-qPCR and flow cytometry analyses. The results showed that only the P. nigra essential oil (PnEO) and α-pinene can increase the transcription of the Glut4/Scl2a4 gene, resulting in a subsequent increase in the amount of GLUT4 produced and its plasma membrane localization. Moreover, the PnEO or α-pinene can induce Glut4 expression both during myogenesis and in myotubes. In summary, the PnEO and α-pinene emulate insulin’s effect on the GLUT4 transporter expression and its translocation to the muscle cell surface. Full article
(This article belongs to the Special Issue Molecular Research on Skeletal Muscle Biology)
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