Antimicrobial Peptides, Cytokines, Chemokines and Danger Molecules in Immunity and Autoimmunity
Deadline for manuscript submissions: 30 April 2024 | Viewed by 413
Interests: autoimmunity; basic immunology; T-cell; B-cell and dendritic cell biology; transplantation; anti-infectious immune response
Special Issues, Collections and Topics in MDPI journals
Antimicrobial peptides and antimicrobial chemokines can act both as protein mediators of specific immunological and non-immunological pathways or as chemo-attractants for immune cells. It is the case of cathelicidin LL37, which has chemo-extractant roles for immune cells and also acts as a “danger signal” and stimulator of the immune response, when bound to nucleic acids, with important effects in immunity and autoimmunity. A similar role is played by CXCL4, also called platelet factor 4 (PF4), which is a chemokine with pleiotropic effector functions but also a trigger of TLR-mediated inflammation in complexes with DNA/RNA. Both LL37 and CXCL4 play a role in immunity and autoimmunity. Other cationic molecules, either produced endogenously in humans or of microbial origin, can have TLR triggering capacity if bound to nucleic acids. Interestingly, these kinds of mediators can also be post-translationally modified during inflammation. In this Research Topic, we invite original articles and reviews illustrating current research and opinions about molecules that have pleiotropic effects on immunity and the effect of their post-translational modifications on health and disease. The topic involves but is not limited to, DNA/RNA binding proteins that exert pro-inflammatory role in immunity and autoimmunity and the effect of post-translational modification on their functions during normal immune responses and in immune-mediated diseases.
Dr. Loredana Frasca
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- antimicrobial peptides
- antimicrobial chemokines
- immune cells
- immune responses