Antibody and Autoantibody Specificities in Autoimmunity

A special issue of Antibodies (ISSN 2073-4468).

Deadline for manuscript submissions: 10 December 2024 | Viewed by 62

Special Issue Editors


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Guest Editor
Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2JA, UK
Interests: autoimmune vitiligo; autoimmune parathyroid disease; autoimmune polyendocrine syndromes; autoimmune thyroid disease; autoantigens; autoantibody

Special Issue Information

Dear Colleagues,

Autoantibodies are a primary characteristic of many systemic autoimmune diseases. In some autoimmune diseases, there are classes of antibodies which are more specific for that particular disease. For instance, in systemic sclerosis (SSc), antibodies which identify the disease, called anti-topoisomerase (ATAs) and anti-centromer antibodies (ACAs), are generated even years before overt disease. However, autoimmune diseases that seem to be different, as they present different clinical manifestations, may share antibody reactivity. For instance, the antimicrobial peptide LL37 is an autoantigen in psoriasis while antibodies to LL37 are also generated in psoriatic arthritis (PsA). However, such antibodies are also highly expressed in systemic lupus erythematous (SLE). The link could be a neutrophil-dominated inflammation, which may be present in SLE kidney or skin, psoriasis skin and in PsA joints.

Interestingly, antibodies present in autoimmune patients can also target post-translationally modified autoantigens, and this may favor the breakage of tolerance. A typical example of this are antibodies generated against citrullinated and carbamoylated self-proteins in rheumatoid arthritis (RA), a phenomenon also occurring in PsA and in SLE. Therefore, understanding the reasons why some antibodies mark only specific diseases whereas others are shared between diseases that affect different organs could shed light on common pathogenic pathways and, ultimately, inspire pharmacological interventions. The study of antibody specificities across several autoimmune diseases may also help to identify more precise and distinct biomarkers.

Biological therapies are widely used in autoimmunity and they can also induce typical antibodies. An example are antibodies generated during anti-TNF-alpha (anti-TNF) therapy for psoriasis or PsA, ankylosing spondylitis, RA, and inflammatory bowel diseases (IBDs). The reason why these antibodies are generated and the ways to counteract this phenomenon are of great importance.

Here, we invite clinical and basic research paper submissions on autoantibodies present in patients, including antibodies directed to post-translationally modified autoantigens, as well as those generated against antibodies used in therapy.

Dr. Loredana Frasca
Dr. E. Helen Kemp
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmunity
  • autoantibodies
  • biological therapy
  • post-translational modified autoantigens

Published Papers

This special issue is now open for submission.
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