Biomarkers and Drug Targets for Longevity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 29 August 2024 | Viewed by 1163
Special Issue Editor
2. Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Interests: risk stratification; lipid-lowering therapy; drug development; atherosclerosis; cardiovascular prevention; epidemiology; meta-analyses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There has recently been high interest in all kinds of biomarkers and interventions that might help to evaluate expected lengths of lives and make it possible to extend lifetimes. This is especially important now, when in last several years, we have observed reductions in life expectancies by even over 2 years in some countries. On the one hand, our knowledge on the prediction of life expectancy seems to be increasingly accurate with the possibility of evaluating concrete biomarkers like telomere length, mitochondria activity and functions, changes in microvascular circulation, microbiome, advanced glycation end products, glycans, and whole-genome analysis. On the other hand, many inconsistencies remain in how to interpret these parameters correctly and, in particular, how they will be affected by concrete and dedicated interventions. This is currently the area of research undergoing the most development, but for most of these parameters, we still do not have clear results on whether they might indeed prolong our life.
As already identified in research, lifestyle factors such as a healthy diet and physical activity play a crucial role in healthy aging, the mechanisms of which mainly include modulating oxidative stress, metabolism, inflammation, genetic regulation, and cell signaling and survival. Lifestyle changes can have major effects on molecular biomarkers, mitochondrial activity, or white blood cell telomere length (LTL). This Special Issue will cover all molecular aspects of promoting longevity, aiming to provide further knowledge on new molecular targets, biomarkers, lifestyle improvement, and other interventions that might help to predict and improve the lifespan. This Special Issue invites submissions of original research and review articles.
Prof. Dr. Maciej Banach
Guest Editor
Manuscript Submission Information
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Keywords
- biomarkers
- drug targets
- genes
- longevity
- mitochondria
- personalized interventions
