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Neutrophil Extracellular Traps (NETs) in Immunity and Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 251

Special Issue Editor

Department of Pediatric Surgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Interests: neutrophils; neutrophil extracellular traps; pediatric diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue on “Neutrophil Extracellular Traps (NETs) in Immunity and Diseases” (https://www.mdpi.com/journal/ijms/special_issues/NETs_immune).

Currently, research in this area has mainly focused on adaptive immune response and its broad application. However, human death rates are highly influenced by diseases such as sepsis, multiresistant microbes, autoimmune disorders and cancer, in which innate immunity plays a leading role. Therefore, greater attention should be paid to the innate immune response, and especially to neutrophils, which play an invaluable role in host immune defence. Cytokines and other stimuli direct these cells into infected tissues, where they eliminate invading microbes. Notably, successful neutrophil defence is often associated with inflammatory tissue damage and diseases including allergy, autoimmune diseases, atherosclerosis, thrombus formation, and metabolic disorders. This has been linked to the capability of activated neutrophils to release decondensed chromatin decorated with granular proteins known as neutrophil extracellular traps (NETs). NETs act as a scaffold for the aggregation of viable, necrotic and apoptotic cells, as well as crystals and microbes. Importantly, under specific conditions, NETs act as an inflammatory or anti-inflammatory process.

Although significant efforts have been made to study NETs’ release, we still need to broaden our knowledge of this unique feature. In terms of the currently available data showing the contribution of NETs to various pathological conditions and cancer metastasis, gaining a deeper understanding of the mechanisms of NETs’ release, as well as their role in the immune response and diseases, is of great importance. Additionally, the degradation of NETs and their clearance is only partially understood and warrants further research.

The focus of this Special Issue is to update current research on NETs in immunity and disease, improving our understanding of this phenomenon and enabling the development of new therapeutic strategies concerning various pathological conditions related to excessive NET release and/or incomplete degradation. Both review and original articles covering basic, translational or clinical molecular-data-supported research are welcome.

Dr. Jasmin Knopf
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neutrophils
  • neutrophil functions
  • neutrophil extracellular traps (NETs)
  • NETs biology
  • NETs in autoimmune diseases
  • NETs in immune response
  • NETs in development and progression of cancer diseases
  • NETs in immunothrombosis, degradation of NETs

Published Papers

This special issue is now open for submission.
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