Formation, Aggregation, Persistence, and Maturation of NETs

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 141

Special Issue Editors


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Guest Editor
1. Department for Internal Medicine 3, University Hospital Erlangen, Institute for Clinical Immunology, Ulmenweg 18, 91054 Erlangrn, Germany
2. Deutsches Zentrum für Immuntherapie, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangrn, Germany
3. Department of Pediatric Surgery, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
Interests: NET formation; NET maturation; inflammation; immunothrombosis
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Guest Editor
Department of Pediatric Surgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Interests: neutrophils; neutrophil extracellular traps; pediatric diseases
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department for Internal Medicine 3, University Hospital Erlangen, Institute for Clinical Immunology, Ulmenweg 18, 91054 Erlangrn, Germany
2. Deutsches Zentrum für Immuntherapie, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangrn, Germany
Interests: innate immunity; inflammation; autoimmunity; anti-tumor immunity; neutrophils
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of General-, Visceral-, Vascular- and Transplant Surgery, University Hospital Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Interests: neutrophils; neutrophil extracellular traps in general, visceral and transplant surgery

Special Issue Information

Dear Colleagues,

Neutrophils are the most abundant leukocytes in human blood and the first line of defense against invading pathogens. They are the first cells recruited to the site of injury and are capable of fighting pathogens via phagocytosis, degranulation, production of reactive oxygen species (ROS) and formation of neutrophil extracellular traps (NETs). The latter are composed of chromatin decorated with neutrophil granular proteins such as myeloperoxidase (MPO) or neutrophil elastase (NE). NETs were first reported in 2004 as a mechanism for neutrophils to trap and kill bacteria. Since then, many other features of NETs have been described. It is now clear that a delicate balance of NET formation and degradation is needed to grant the beneficial effects of NETs and prevent the contribution to pathological states such as autoimmune diseases, lithiasis, aberrant anti-cancer responses or immunothrombosis. This Special Issue of Cells invites all authors to contribute with original research, review or communications exploring the formation, aggregation, persistence and maturation of NETs in tissues during health and disease.

Prof. Dr. Martin Herrmann
Dr. Jasmin Knopf
Dr. Luis E. Munoz
Dr. Maximilian Dölling
Guest Editors

Manuscript Submission Information

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Keywords

  • mechanisms of NET formation
  • NETs in diseases
  • degradation of NETs
  • NET therapeuticals
  • benefical NETs

Published Papers

This special issue is now open for submission.
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