Neuronal Inclusions in Neurodegeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 1101
Special Issue Editor
Interests: neuroanatomy; neuroscience; neurodegeneration; methamphetamine; autophagy; movement disorders; substances of abuse; morphology; ultrastructure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The occurrence of neuronal (and glial inclusions) is a common hallmark in neurodegenerative disorders.
This phenomenon encompasses the central and peripheral nervous system and extends to neural tissue, which is present within sensory organs. Additionally, the occurrence of neuronal inclusions dates back to the beginning of the XIX century when the occurrence of Lafora bodies and Lewy bodies was first described. The nature of these formations is still a matter of debate and it represents a popular topic for understanding the biology of neurodegenerative diseases.
Two main points are crucial at present within this field. The first point relates to the structure of these inclusions which has recently been rejuvenated by seminal papers showing the occurrence of a number of chemical species, membrane organelles and various proteins surpassing at large the classic single or few protein-based visions, which have been predominant until very recent times.
The other facet concerns the significance of the inclusions in the dynamics of the disease. Are they detrimental to and do they participate in the process of cell damage and cell death? Or, vice versa, do they represent an attempt (often successful) to trap and neutralize toxic molecules and dysfunctional organelles?
The Special Issue will be dedicated to manuscript reviewing or reporting the data on the various types of inclusions which occur in the central and peripheral nervous system, including muscles and sensory organs.
Descriptive papers are welcome along with data-based manuscripts showing the structure of inclusions through classic and innovative techniques. The role of the inclusion in the dynamics of the disease and the biochemical cascades involved in inclusion formation will be highly appreciated. The Special Issue also aims to provide a historical perspective about the seminal research steps which have contributed in the last couple of centuries to defining neuronal inclusions. The pharmacological and therapeutic approaches that modulate the occurrence of neuronal inclusions within all different districts of the body and across different species are also welcome.
Prof. Dr. Francesco Fornai
Guest Editor
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