Abnormal Organelles and Protein Expression in Acute and Chronic Neurodegeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 July 2024 | Viewed by 66
Special Issue Editor
Interests: neuroanatomy; neuroscience; neurodegeneration; methamphetamine; autophagy; movement disorders; substances of abuse; morphology; ultrastructure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In defining neurodegenerative disorders, we now include both slow chronic events which occur typically in Parkinson’s disease and degenerative dementia, as well as sudden acute neuronal loss, which recapitulates within a condensed time interval with most molecular events taking place in classic degenerative disorders, as demonstrated within ischemic penumbra following an ischemic stroke or prolonged epileptic discharges within epileptic penumbra. In keeping with such a wide definition of neurodegeneration, we should also include abnormal events which take place within neurons during reiterated exposure to drugs of abuse, which characterize neurodegeneration in the addicted brain. Similarly, psychiatric disorders such as bipolar disorders may feature degenerative phenomena.
In all conditions, a specific alteration to key organelles can often be described, and altered protein expression and protein clearance occur per se or related to the dysfunctional clearance organelles such as the autophagosomes, lysosomes, etc. The aim of this Special Issue is to gather evidence from various research field which share similar steps in producing a loss of neuronal integrity within specific brain areas ex vivo and in vivo, cell lines in vitro or protein conformation within in tubo systems. As such, the Special Issue focuses on collecting various findings from different research fields to represent a comprehensive overview of the pathways and subcellular components which characterize a variety of degenerative phenomena. Such a multi-faceted approach should attract scientists from different fields of neuroscience with expertise in various methods and topics.
Prof. Dr. Francesco Fornai
Guest Editor
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Keywords
- brain ischemia
- epileptic damage
- basal ganglia pathology
- catecholamine cell damage
- excitotoxicity
- autophagy
- dopamine system norepinephrine system
- protein unfolding
- protein misfolding
- cholinergic system
