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Dear Colleagues,

Regenerative medicine has emerged as a promising field in healthcare, offering innovative solutions for the treatment of tissue injuries, degenerative diseases, and organ failures. It involves research in multiple areas including tissue engineering, polymer chemistry, biochemistry, nanotechnology, stem cell therapy, molecular biology and pharmacology.

Biomaterials play a pivotal role in regenerative medicine and biomedical technologies, serving as scaffolds, carriers, and therapeutic agents to facilitate tissue repair, organ regeneration and disease treatment. The biomaterials for tissue regeneration have to be properly designed to make them biocompatible, bioactive, and able to exhibit specific biophysical and biochemical characteristics.

As guest editors, we are pleased to encourage all academic and industry researchers to submit high-quality reviews or original articles related to the issues in this research area highlighting the current state-of-art and innovative strategies for regenerative medicine.

Dr. Simona Campora
Dr. Francesco Lopresti
Guest Editors

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Keywords

biomaterial
tissue engineering
regenerative medicine
biomedical technologies
stem cell
nanotechnology
scaffolds

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27 pages, 15823 KiB

Open AccessArticle

Improvement of Osteogenic Differentiation of Mouse Pre-Osteoblastic MC3T3-E1 Cells on Core–Shell Polylactic Acid/Chitosan Electrospun Scaffolds for Bone Defect Repair

by Francesco Lopresti, Simona Campora, Salvatrice Rigogliuso, Aldo Nicosia, Alessandra Lo Cicero, Chiara Di Marco, Salvatore Tornabene, Giulio Ghersi and Vincenzo La Carrubba

Int. J. Mol. Sci. 2024, 25(5), 2507; https://doi.org/10.3390/ijms25052507 - 21 Feb 2024

Viewed by 636

Abstract

Electrospun hybrid scaffolds composed of synthetic and natural polymers have gained increasing interest in tissue engineering applications over the last decade. In this work, scaffolds composed of polylactic acid electrospun fibers, either treated (P-PLA) or non-treated (PLA) with air-plasma, were coated with high molecular weight chitosan to create a core–shell microfibrous structure. The effective thickness control of the chitosan layer was confirmed by gravimetric, spectroscopic (FTIR-ATR) and morphological (SEM) investigations. The chitosan coating increased the fiber diameter of the microfibrous scaffolds while the tensile mechanical tests, conducted in dry and wet environments, showed a reinforcing action of the coating layer on the scaffolds, in particular when deposited on P-PLA samples. The stability of the Chi coating on both PLA and P-PLA substrates was confirmed by gravimetric analysis, while their mineralization capacity was evaluated though scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) after immersing the scaffolds in simulated body fluids (SBF) at 37 °C for 1 week. Sample biocompatibility was investigated through cell viability assay and SEM analysis on mouse pre-osteoblastic MC3T3-E1 cells grown on scaffolds at different times (1, 7, 14 and 21 days). Finally, Alizarin Red assay and qPCR analysis suggested that the combination of plasma treatment and chitosan coating on PLA electrospun scaffolds influences the osteoblastic differentiation of MC3T3-E1 cells, thus demonstrating the great potential of P-PLA/chitosan hybrid scaffolds for bone tissue engineering applications. Full article

(This article belongs to the Special Issue Current Trends in Biomaterials for Regenerative Medicine)

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