Electrospun Membranes for Biomedical Applications

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Membrane Applications".

Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 4056

Special Issue Editors


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Guest Editor
Department of Engineering, University of Palermo, I-90128 Palermo, Italy
Interests: tissue engineering; biomaterials

Special Issue Information

Dear Colleagues,

This Special Issue is devoted to “Electrospun Membranes for Biomedical Applications”, including biopolymer blends and nanocomposites. Electrospinning is a versatile process technology, exploited for the production of fibers with varying diameters, ranging from nano- to micro-scale. The unique properties of electrospun mats make them a potential candidate for a plethora of commercial applications in medical fields such as drug delivery systems, tissue engineering, biosensing, and components for microfluidic circuitry.

Therefore, papers are sought that deal with the relationships between processing, structure, morphology, and properties in electrospun polymeric membranes, either providing new insights on the interaction between membranes and cells or investigating hybrid technologies that include electrospun membranes, leading to improved performance in tissue engineering, drug release, and biosensing applications. The latest research dealing with special biomedical application fields and/or proposing novel characterization protocols will also be of great interest.

Potential topics include but are not limited to the following:

  • Processing–properties–structure relationships of electrospun membranes for biomedical applications;
  • Drug release from electrospun membranes;
  • Electrospun membranes for lab-on-a-chip devices;
  • Electrospun membranes for biosensing;
  • Bulk and surface properties of electrospun membranes;
  • Effect of blends/filler on electrospun membranes.

Dr. Francesco Lopresti
Prof. Dr. Francesco Carfì Pavia 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • Processing–properties–structure relationships
  • Drug release
  • Tissue engineering
  • Lab-on-a-chip
  • Biosensing
  • Biomechanical properties
  • Degradation
  • Polymer blends
  • Bionanocomposites

Published Papers (1 paper)

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Research

18 pages, 7160 KiB  
Article
Engineered Membranes for Residual Cell Trapping on Microfluidic Blood Plasma Separation Systems: A Comparison between Porous and Nanofibrous Membranes
by Francesco Lopresti, Ieva Keraite, Alfredo Edoardo Ongaro, Nicola Marie Howarth, Vincenzo La Carrubba and Maïwenn Kersaudy-Kerhoas
Membranes 2021, 11(9), 680; https://doi.org/10.3390/membranes11090680 - 31 Aug 2021
Cited by 7 | Viewed by 3513
Abstract
Blood-based clinical diagnostics require challenging limit-of-detection for low abundance, circulating molecules in plasma. Micro-scale blood plasma separation (BPS) has achieved remarkable results in terms of plasma yield or purity, but rarely achieving both at the same time. Here, we proposed the first use [...] Read more.
Blood-based clinical diagnostics require challenging limit-of-detection for low abundance, circulating molecules in plasma. Micro-scale blood plasma separation (BPS) has achieved remarkable results in terms of plasma yield or purity, but rarely achieving both at the same time. Here, we proposed the first use of electrospun polylactic-acid (PLA) membranes as filters to remove residual cell population from continuous hydrodynamic-BPS devices. The membranes hydrophilicity was improved by adopting a wet chemistry approach via surface aminolysis as demonstrated through Fourier Transform Infrared Spectroscopy and Water Contact Angle analysis. The usability of PLA-membranes was assessed through degradation measurements at extreme pH values. Plasma purity and hemolysis were evaluated on plasma samples with residual red blood cell content (1, 3, 5% hematocrit) corresponding to output from existing hydrodynamic BPS systems. Commercially available membranes for BPS were used as benchmark. Results highlighted that the electrospun membranes are suitable for downstream residual cell removal from blood, permitting the collection of up to 2 mL of pure and low-hemolyzed plasma. Fluorometric DNA quantification revealed that electrospun membranes did not significantly affect the concentration of circulating DNA. PLA-based electrospun membranes can be combined with hydrodynamic BPS in order to achieve high volume plasma separation at over 99% plasma purity. Full article
(This article belongs to the Special Issue Electrospun Membranes for Biomedical Applications)
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