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Molecular Research on Cardiac Regenerative Medicine
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Molecular Research on Cardiac Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 775

Special Issue Editor

Dr. Ken Takahashi

E-Mail Website
Guest Editor
Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
Interests: cardiovascular regenerative medicine; ischemia-reperfusion injury; space medicine/biology

Special Issue Information

Dear Colleagues,

Heart failure poses a significant threat to human health. However, with the advancement of cell culture technologies, such as human induced pluripotent stem cells (hiPSCs) and 3D bioprinting, the field of cardiac regenerative medicine is thriving. For this Special Issue, we are inviting a wide range of molecular scientific research papers and review articles related to cardiac regenerative medicine. While we anticipate contributions in areas such as cell biology, stem cells, biotechnology, extracellular matrix, mechanobiology, bioprinting, tissue transplantation, etc., we are not limiting invited works to these fields. We look forward to receiving research findings that significantly contribute to the advancement of cardiac regenerative medicine.

Dr. Ken Takahashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • human induced pluripotent stem cells
  • hiPSCs
  • 3D bioprinting
  • regenerative medicine
  • tissue engineering

Published Papers (1 paper)

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Research

17 pages, 14797 KiB  
Article
Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells
by Kazuko E. Schmidt, Anna L. Höving, Katja Nowak, Nike an Mey, Sina Kiani Zahrani, Britta Nemeita, Lena Riedel, Agnes Majewski, Barbara Kaltschmidt, Cornelius Knabbe and Christian Kaltschmidt
Int. J. Mol. Sci. 2024, 25(7), 3593; https://doi.org/10.3390/ijms25073593 - 22 Mar 2024
Viewed by 554
Abstract
Cardiovascular diseases (CVDs) are often linked to ageing and are the major cause of death worldwide. The declined proliferation of adult stem cells in the heart often impedes its regenerative potential. Thus, an investigation of the proliferative potential of adult human cardiac stem [...] Read more.
Cardiovascular diseases (CVDs) are often linked to ageing and are the major cause of death worldwide. The declined proliferation of adult stem cells in the heart often impedes its regenerative potential. Thus, an investigation of the proliferative potential of adult human cardiac stem cells (hCSCs) might be of great interest for improving cell-based treatments of cardiovascular diseases. The application of human blood serum was already shown to enhance hCSC proliferation and reduce senescence. Here, the underlying signalling pathways of serum-mediated hCSC proliferation were studied. We are the first to demonstrate the involvement of the transcription factor NF-κB in the serum-mediated proliferative response of hCSCs by utilizing the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC). RNA-Sequencing (RNA-Seq) revealed ATF6B, COX5B, and TNFRSF14 as potential targets of NF-κB that are involved in serum-induced hCSC proliferation. Full article
(This article belongs to the Special Issue Molecular Research on Cardiac Regenerative Medicine)
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