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Gels
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Advances in Acrylate-Based Hydrogels
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Advances in Acrylate-Based Hydrogels

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5038

Special Issue Editors

Dr. Yuqi Jin

E-Mail
Guest Editor
Center for Agile and Adaptive Additive Manufacturing (CAAAM), University of North Texas, Denton, TX 76203, USA
Interests: additive manufacturing; acoustics; hydrogels
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Arup Neogi

E-Mail Website
Guest Editor
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 611731, China
Interests: nanotechnology; photonics; ultrafast spectroscopy; biophotonics; ultrasonic

Special Issue Information

Dear Colleagues,

This Special Issue is aimed at recent broad developments in acrylate-based hydrogels in the science and engineering fields. Due to freedom of composition and internal bonding modifications, acrylate-based hydrogels can have particularly distinguishable physical, chemical, and biological properties. Based on this, acrylate-based hydrogels have been studied and applied in varied fields, including 3D prints, robotics, biomedicines, environments, optics, acoustics, and so on. Thus, this Special Issue will collect papers on the application directions in the field, which will be of interest to the entire scientific community. Contributions in the form of reviews and original studies are both welcome.

Dr. Yuqi Jin
Prof. Dr. Arup Neogi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D and 4D printings
  • tunable hydrogels
  • curing and degradation
  • physical properties’ characterization
  • soft robotics
  • shape memory hydrogels
  • sensing
  • micro- and nanocomposite hydrogels
  • antifouling
  • biomedicines

Published Papers (2 papers)

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Research

12 pages, 2683 KiB  
Article
Polyglycerol-Based Hydrogel as Versatile Support Matrix for 3D Multicellular Tumor Spheroid Formation
by Boonya Thongrom, Peng Tang, Smriti Arora and Rainer Haag
Gels 2023, 9(12), 938; https://doi.org/10.3390/gels9120938 - 29 Nov 2023
Viewed by 1121
Abstract
Hydrogel-based artificial scaffolds are essential for advancing cell culture models from 2D to 3D, enabling a more realistic representation of physiological conditions. These hydrogels can be customized through crosslinking to mimic the extracellular matrix. While the impact of extracellular matrix scaffolds on cell [...] Read more.
Hydrogel-based artificial scaffolds are essential for advancing cell culture models from 2D to 3D, enabling a more realistic representation of physiological conditions. These hydrogels can be customized through crosslinking to mimic the extracellular matrix. While the impact of extracellular matrix scaffolds on cell behavior is widely acknowledged, mechanosensing has become a crucial factor in regulating various cellular functions. cancer cells’ malignant properties depend on mechanical cues from their microenvironment, including factors like stiffness, shear stress, and pressure. Developing hydrogels capable of modulating stiffness holds great promise for better understanding cell behavior under distinct mechanical stress stimuli. In this study, we aim to 3D culture various cancer cell lines, including MCF-7, HT-29, HeLa, A549, BT-474, and SK-BR-3. We utilize a non-degradable hydrogel formed from alpha acrylate-functionalized dendritic polyglycerol (dPG) and thiol-functionalized 4-arm polyethylene glycol (PEG) via the thiol-Michael click reaction. Due to its high multivalent hydroxy groups and bioinert ether backbone, dPG polymer was an excellent alternative as a crosslinking hub and is highly compatible with living microorganisms. The rheological viscoelasticity of the hydrogels is tailored to achieve a mechanical stiffness of approximately 1 kPa, suitable for cell growth. Cancer cells are in situ encapsulated within these 3D network hydrogels and cultured with cell media. The grown tumor spheroids were characterized by fluorescence and confocal microscopies. The average grown size of all tumoroid types was ca. 150 µm after 25 days of incubation. Besides, the stability of a swollen gel remains constant after 2 months at physiological conditions, highlighting the nondegradable potential. The successful formation of multicellular tumor spheroids (MCTSs) for all cancer cell types demonstrates the versatility of our hydrogel platform in 3D cell growth. Full article
(This article belongs to the Special Issue Advances in Acrylate-Based Hydrogels)
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13 pages, 11614 KiB  
Article
Comprehensive Optimization of Western Blotting
by Dishiwen Liu, Haoliang Wu, Shengyu Cui and Qingyan Zhao
Gels 2023, 9(8), 652; https://doi.org/10.3390/gels9080652 - 14 Aug 2023
Viewed by 3455
Abstract
Western blotting is one of the most extensively used techniques in the biomedical field. However, it is criticized by many researchers due to its considerable time consumption, multiple steps, and low method results. Therefore, we modified the steps of gel preparation, electrophoresis, electrotransfer, [...] Read more.
Western blotting is one of the most extensively used techniques in the biomedical field. However, it is criticized by many researchers due to its considerable time consumption, multiple steps, and low method results. Therefore, we modified the steps of gel preparation, electrophoresis, electrotransfer, blocking, and gel cutting. First, we simplified the gel preparation step by premixing various reagents and varying the amounts of catalysts or radical generators, which shortened the entire process to 10 min. Second, we shortened the electrophoresis process to 35 min by modifying the formula of the electrophoresis running buffer. Then, we removed the hazard of methanol vapor by replacing methanol with ethanol in the electrotransfer buffer. Finally, the use of polyvinylpyrrolidone-40 shortened the blocking procedure to 10 min. Our modifications shortened the time, improved the experimental productivity, and minimized the experimental cost without hindering compatibility with most existing equipment. The entire experiment up to primary antibody incubation can be completed within 80 min. Full article
(This article belongs to the Special Issue Advances in Acrylate-Based Hydrogels)
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