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Gels
Special Issues
Gels for Wound Healing
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Gels for Wound Healing

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 6079

Special Issue Editors

Dr. Ruiqi Xie

E-Mail Website
Guest Editor
1. State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China
2. Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, Chongqing 400715, China
Interests: smart biomaterial; wound healing; hemostasis; gel-based biomaterials; biomimetics, nanotechnology; tissue regeneration
Dr. Wenyi Wang

E-Mail Website
Guest Editor
Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong 999077, China
Interests: clinical application of gel-based biomedical materials; design and fabrication of transdermal drug delivery systems; herbal therapy for atopic dermatitis; development of healthcare textile; gels
Special Issues, Collections and Topics in MDPI journals
Dr. Bitao Lu

E-Mail Website
Guest Editor
State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China
Interests: nano/micro drug delivery systems; fibrous medical materials; biomimic materials for wound healing and hemostasis; gels

Special Issue Information

Dear Colleagues,

Wounds frequently cause pain, inflammation, loss of function, and even amputations or sepsis, lowering a patient's quality of life and increasing their financial costs. Wound healing is a complex process that is hampered by a number of unresolved therapeutic issues that impair healing capacity to replace damaged and dysfunctional cellular structures and tissue layers. These difficulties include managing the inflammatory state (particularly in chronic wounds), regulating angiogenesis, scarring reduction, and mechanical augmentation. Gels could be used as a platform to deliver drugs and accomplish antibacterial effects, to provide a moist environment for cell migration, as well as to absorb some exudate. Given these benefits, gels are a particularly desirable sort of wound-healing solution that was developed for drug delivery, inflammation management, scar reduction, and leading to healthier, firmer skin.

This Special Issue, titled Gels for Wound Healing, aims to focus on the latest research progress on gel-based materials that may facilitate the four stages of wound healing (hemostasis, inflammation, proliferation, and maturation). This Special Issue covers a wide spectrum of research from material design to translational and clinical studies. Authors are welcome to submit both articles and review papers.

Dr. Ruiqi Xie
Dr. Wenyi Wang
Dr. Bitao Lu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • hydrogel
  • aerogel
  • tissue regeneration
  • drug delivery
  • hemostasis
  • biomaterials

Published Papers (3 papers)

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Research

11 pages, 1036 KiB  
Communication
Effect of Gelatin-Based Hemostats on Fibroblasts and Relevant Growth Factors in Wound Healing
by Waseem Garabet, Polina Shabes, Katharina Henrika Wolters, Julian-Dario Rembe, Wiebke Ibing, Markus Udo Wagenhäuser, Florian Simon, Hubert Schelzig and Alexander Oberhuber
Gels 2023, 9(6), 504; https://doi.org/10.3390/gels9060504 - 20 Jun 2023
Cited by 1 | Viewed by 1238
Abstract
Gelatin-based hemostats have been used in various surgical fields and showed advantageous effects on central aspects of wound healing when compared to cellulose-based hemostats. Nevertheless, the influence of gelatin-based hemostats on wound healing has not been fully explored yet. Hemostats were applied to [...] Read more.
Gelatin-based hemostats have been used in various surgical fields and showed advantageous effects on central aspects of wound healing when compared to cellulose-based hemostats. Nevertheless, the influence of gelatin-based hemostats on wound healing has not been fully explored yet. Hemostats were applied to fibroblast cell cultures for 5, 30, 60 min, 24 h, 7 and 14 days and measurements were taken at 3, 6, 12, 24 h and 7 or 14 days, respectively. Cell proliferation was quantified after different exposure times and a contraction assay was conducted to measure the extent of the extracellular matrix over time. We further assessed quantitative levels of vascular endothelial growth factor and basic fibroblast growth factor using enzyme-linked immunosorbent assay. Fibroblast counts decreased significantly at 7 and 14 days independent of the application duration (p < 0.001 for 5 min application). The gelatin-based hemostat did not have a negative impact on cell matrix contraction. After application of gelatin-based hemostat, the basic fibroblast growth factor did not change; yet, the vascular endothelial growth factor significantly increased after a prolonged 24 h application time when compared to controls or to a 6 h exposure (p < 0.05). Gelatin-based hemostats did not impair contraction of the extracellular matrix or growth factor production (vascular endothelial growth factor and basic fibroblast growth factor), while cell proliferation diminished at late time points. In conclusion, the gelatin-based material seems to be compatible with central aspects of wound healing. For further clinical assessment, future animal and human studies are necessary. Full article
(This article belongs to the Special Issue Gels for Wound Healing)
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16 pages, 8615 KiB  
Article
Effects of Platelet Lysate Gels Derived from Different Blood Sources on Oral Mucosal Wound Healing: An In Vitro Study
by Sook-Luan Ng, Nur Ain Azhar, Siti Balkis Budin, Norliwati Ibrahim, Nur Azurah Abdul Ghani, Norzana Abd Ghafar and Jia-Xian Law
Gels 2023, 9(4), 343; https://doi.org/10.3390/gels9040343 - 17 Apr 2023
Cited by 2 | Viewed by 1557
Abstract
The rapid healing of oral ulcers is important to prevent secondary infection, especially for chronic oral ulcers. Platelet lysate (PL) is rich in growth factors for cell growth and promotes tissue regeneration. Hence, this study was performed to compare the effects of PL [...] Read more.
The rapid healing of oral ulcers is important to prevent secondary infection, especially for chronic oral ulcers. Platelet lysate (PL) is rich in growth factors for cell growth and promotes tissue regeneration. Hence, this study was performed to compare the effects of PL originating from umbilical cord blood (CB) and peripheral blood (PB) on oral mucosal wound healing. The PLs were molded into gel form in the culture insert with the addition of calcium chloride and conditioned medium for sustained release of growth factors. The CB-PL and PB-PL gels were found to degrade slowly in culture and their degradation percentages by weight were 5.28 ± 0.72% and 9.55 ± 1.82% respectively. The results from the scratch assay and Alamar blue assay showed that the CB-PL and PB-PL gels increased the proliferation (148 ± 3% and 149 ± 3%) and wound closure (94.17 ± 1.77% and 92.75 ± 1.80%) of oral mucosal fibroblasts compared to the control with no statistical differences between the two gels, respectively. Quantitative RT-PCR showed that mRNA expressions of collagen-I, collagen-III, fibronectin, and elastin genes in cells treated with CB-PL (11-, 7-, 2-, and 7-fold) and PB-PL (17-, 14-, 3-, and 7-fold) decreased compared with the control, respectively. The concentration of platelet-derived growth factor of PB-PL gel (1303.10 ± 343.96 pg/mL) showed a higher trend than CB-PL gel did (905.48 ± 69.65 pg/mL) from ELISA measurement. In summary, CB-PL gel is as effective as PB-PL gel in supporting oral mucosal wound healing, making it a potential new source of PL for regenerative treatment. Full article
(This article belongs to the Special Issue Gels for Wound Healing)
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Graphical abstract

20 pages, 6171 KiB  
Article
Diosmin-Loaded Nanoemulsion-Based Gel Formulation: Development, Optimization, Wound Healing and Anti-Inflammatory Studies
by Md. Khalid Anwer, Mohammed F. Aldawsari, Muzaffar Iqbal, Bjad K. Almutairy, Gamal A. Soliman and M. Ali Aboudzadeh
Gels 2023, 9(2), 95; https://doi.org/10.3390/gels9020095 - 22 Jan 2023
Cited by 4 | Viewed by 2761
Abstract
The wound-healing process is complex and prone to interruption or failure, which can result in the development of chronic wounds that never heal. This can be overcome by seeking prompt medical attention, which will reduce the likelihood of complications and speed up the [...] Read more.
The wound-healing process is complex and prone to interruption or failure, which can result in the development of chronic wounds that never heal. This can be overcome by seeking prompt medical attention, which will reduce the likelihood of complications and speed up the healing of the cutaneous wound. It has been established that functionalized engineered biomaterials are a possible strategy for starting skin wound care. The purpose of the current study is to develop a diosmin (DSM)-loaded nanoemulsion (NE)-based gel formulation and to investigate its wound healing and anti-inflammatory activity on rats. The DSM-loaded NEs (F1-F17) were developed and optimized with the help of Box–Behnken Design Expert. The DSM-Nes were developed using lauroglycol 90 (LG90®) as oil, Tween-80 as surfactant and transcutol-HP (THP) as co-surfactant. The optimized Nes showed globule size (41 ± 0.07 nm), polydispersity index (PDI) (0.073 ± 0.008) and percentage of entrapment efficiency (%EE) (87 ± 0.81%). This optimized DSM-loaded NEs (F1) was further evaluated and incorporated into 1% carbopol 940 gel. F1-loaded gel was then characterized for drug content, spreadability, in vitro release, wound healing, and anti-inflammatory studies. The developed gel of DSM was found to show significantly better (p < 0.05) wound-healing and anti-inflammatory activity. Full article
(This article belongs to the Special Issue Gels for Wound Healing)
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