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Gels
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Multifunctional Hydrogel for Wound Healing and Tissue Repair
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Multifunctional Hydrogel for Wound Healing and Tissue Repair

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 4998

Special Issue Editors

Dr. Jiafu Cao

E-Mail Website
Guest Editor
State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
Interests: nanomedicine; drug delivery systems; tissue engineering; hydrogels; biomaterials; wound healing; infectious diseases; nitric oxide delivery
Prof. Dr. Jin-Wook Yoo

E-Mail Website
Guest Editor
College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea
Interests: nanomedicine; colon-targeted delivery; wound healing; nitric oxide delivery; infectious diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wounds often cause pain, inflammation, loss of function, and even amputation or sepsis, seriously threatening human health and life. Wound dressings are essential for repairing skin defects and rebuilding skin function. Among the many wound dressings, hydrogels show great application potential in wound healing because they can provide a moist wound environment, prevent secondary infection, promote the autolytic debridement of necrotic wounds and granulation wounds, and improve wound healing efficiency, which is an ideal wound dressing.

With the innovation and development of hydrogel design scheme and synthesis technology, as well as the in-depth study of skin wound repair mechanisms, the function of hydrogels has developed from simple wound covering in the early stage to today's multifunctional intelligent repair (such as antibacterial, antioxidant, anti-inflammatory, angiogenesis, etc.), and their versatility has also shown an increasing trend year on year.

This Special Issue aims to highlight the latest research progress of multifunctional hydrogels as tools for wound healing and tissue repair, covering a wide range of research on hydrogels from material design to translational and clinical research. Authors are welcome to submit and review at the same time.

Dr. Jiafu Cao
Prof. Dr. Jin-Wook Yoo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multifunctional hydrogel
  • wound healing
  • diabetic wounds
  • antibacterial
  • anti-inflammatory
  • drug delivery
  • biomaterials
  • stimuli-responsive
  • tissue engineering

Published Papers (3 papers)

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Research

18 pages, 4136 KiB  
Article
Dual-Delivery Temperature-Sensitive Hydrogel with Antimicrobial and Anti-Inflammatory Brevilin A and Nitric Oxide for Wound Healing in Bacterial Infection
by Linghui Ruan, Chengfeng Pan, Xianting Ran, Yonglan Wen, Rui Lang, Mei Peng, Jiafu Cao and Juan Yang
Gels 2024, 10(4), 219; https://doi.org/10.3390/gels10040219 - 24 Mar 2024
Viewed by 665
Abstract
Bacterial infections impede the wound healing process and can trigger local or systemic inflammatory responses. Therefore, there is an urgent need to develop a dressing with antimicrobial and anti-inflammatory properties to promote the healing of infected wounds. In this study, BA/COs/NO-PL/AL hydrogels were [...] Read more.
Bacterial infections impede the wound healing process and can trigger local or systemic inflammatory responses. Therefore, there is an urgent need to develop a dressing with antimicrobial and anti-inflammatory properties to promote the healing of infected wounds. In this study, BA/COs/NO-PL/AL hydrogels were obtained by adding brevilin A (BA) camellia oil (CO) submicron emulsion and nitric oxide (NO) to hydrogels consisting of sodium alginate (AL) and Pluronic F127 (PL). The hydrogels were characterized through dynamic viscosity analysis, differential scanning calorimetry, and rheology. They were evaluated through anti-inflammatory, antimicrobial, and wound healing property analyses. The results showed that BA/COs/NO-PL/AL hydrogels were thermo-responsive and had good ex vivo and in vivo anti-inflammatory activity, and they also exhibited strong antimicrobial activity against methicillin-resistant Staphylococcus aureus Pseudomonas aeruginosa (MRPA) and methicillin-resistant Staphylococcus aureus (MRSA). They were able to effectively promote healing of the infected wound model and reduce inflammation and bacterial burden. H&E and Masson’s staining showed that BA/COs/NO-PL/AL hydrogels promoted normal epithelial formation and collagen deposition. In conclusion, BA/COs/NO-PL/AL hydrogels are promising candidates for promoting the healing of infected wounds. Full article
(This article belongs to the Special Issue Multifunctional Hydrogel for Wound Healing and Tissue Repair)
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19 pages, 4300 KiB  
Article
Synthesis and Evaluation of Functionalized Polyurethanes for pH-Responsive Delivery of Compounds in Chronic Wounds
by Zhongyan Li, Matthew Crago, Timothy Schofield, Haoxiang Zeng, Heema Kumari Nilesh Vyas, Markus Müllner, Anne Mai-Prochnow, Syamak Farajikhah, Sina Naficy, Fariba Dehghani and Sepehr Talebian
Gels 2023, 9(8), 611; https://doi.org/10.3390/gels9080611 - 28 Jul 2023
Cited by 1 | Viewed by 1741
Abstract
Chronic wounds, depending on the bacteria that caused the infection, can be associated with an extreme acidic or basic pH. Therefore, the application of pH-responsive hydrogels has been instigated for the delivery of therapeutics to chronic wounds. Herein, with the aim of developing [...] Read more.
Chronic wounds, depending on the bacteria that caused the infection, can be associated with an extreme acidic or basic pH. Therefore, the application of pH-responsive hydrogels has been instigated for the delivery of therapeutics to chronic wounds. Herein, with the aim of developing a flexible pH-responsive hydrogel, we functionalized hydrophilic polyurethanes with either cationic (polyethylene imine) or anionic (succinic anhydride) moieties. A comprehensive physicochemical characterization of corresponding polymers was carried out. Particularly, when tested in aqueous buffers, the surface charge of hydrogel films was closely correlated with the pH of the buffers. The loading of the cationic and anionic hydrogel films with various compound models (bromophenol blue; negatively charged or Pyronin Y; positively charged) showed that the electrostatic forces between the polymeric backbone and the compound model will determine the ultimate release rate at any given pH. The potential application of these films for chronic wound drug delivery was assessed by loading them with an antibiotic (ciprofloxacin). In vitro bacterial culturing was performed using Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Results showed that at the same drug dosage, different release profiles achievable from cationic and anionic polyurethanes can yield different degrees of an antibacterial effect. Overall, our results suggest the potential application of cationic and anionic hydrophilic polyurethanes as flexible pH-responsive materials for the delivery of therapeutics to chronic wounds. Full article
(This article belongs to the Special Issue Multifunctional Hydrogel for Wound Healing and Tissue Repair)
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20 pages, 5237 KiB  
Article
Bigel Formulations of Nanoencapsulated St. John’s Wort Extract—An Approach for Enhanced Wound Healing
by Yoana Sotirova, Viliana Gugleva, Stanila Stoeva, Iliyan Kolev, Rositsa Nikolova, Maria Marudova, Krastena Nikolova, Yoana Kiselova-Kaneva, Minka Hristova and Velichka Andonova
Gels 2023, 9(5), 360; https://doi.org/10.3390/gels9050360 - 25 Apr 2023
Cited by 4 | Viewed by 2173
Abstract
This study aimed to develop a semisolid vehicle for topical delivery of nanoencapsulated St. John’s wort (SJW) extract, rich in hyperforin (HP), and explore its wound-healing potential. Four nanostructured lipid carriers (NLCs) were obtained: blank and HP-rich SJW extract-loaded (HP-NLC). They comprised glyceryl [...] Read more.
This study aimed to develop a semisolid vehicle for topical delivery of nanoencapsulated St. John’s wort (SJW) extract, rich in hyperforin (HP), and explore its wound-healing potential. Four nanostructured lipid carriers (NLCs) were obtained: blank and HP-rich SJW extract-loaded (HP-NLC). They comprised glyceryl behenate (GB) as a solid lipid, almond oil (AO), or borage oil (BO) representing the liquid lipid, along with polyoxyethylene (20) sorbitan monooleate (PSMO) and sorbitan monooleate (SMO) as surfactants. The dispersions demonstrated anisometric nanoscale particles with acceptable size distribution and disrupted crystalline structure, providing entrapment capacity higher than 70%. The carrier exhibiting preferable characteristics (HP-NLC2) was gelled with Poloxamer 407 (PM407) to serve as the hydrophilic phase of a bigel, to which the combination of BO and sorbitan monostearate (SMS) organogel was added. The eight prepared bigels with different proportions (blank and nanodispersion-loaded) were characterized rheologically and texturally to investigate the impact of the hydrogel-to-oleogel ratio. The therapeutic potential of the superior formulation (HP-NLC-BG2) was evaluated in vivo on Wistar male rats through the tensile strength test on a primary-closed incised wound. Compared with a commercial herbal semisolid and a control group, the highest tear resistance (7.764 ± 0.13 N) was achieved by HP-NLC-BG2, proving its outstanding wound-healing effect. Full article
(This article belongs to the Special Issue Multifunctional Hydrogel for Wound Healing and Tissue Repair)
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