Gel Dosimetry (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1727

Special Issue Editors


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Guest Editor
Department of Physics “Aldo Pontremoli”, University of Milan, 20133 Milan, Italy
Interests: radiation chemistry; polymers; nano-particles
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Physics “Aldo Pontremoli”, University of Milan, 20133 Milan, Italy
Interests: applied physics; medical physics; dosimetry; material sciences
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are grateful to all authors, reviewers, and readers for their responses to the first volume of our Special Issue on “Gel Dosimetry”. You can access these articles for free via the website:

Gel Dosimetry (1st Edition)

Advances in radiotherapy technology during the last 25 years have significantly improved both dose conformation to tumors and the preservation of healthy tissues, achieving almost realtime feedback by means of high-precision treatments and theranostics. Owing to this, developing high-performance systems capable of coping with the challenging requirements of modern ionizing radiation is a key issue to overcome the limitations of 1D and 2D conventional dosimeters. In this context, “Gel dosimetry” is the most promising tool for the evaluation of 3D high-spatial-resolution dose distributions, and the studies about these materials represent the starting point for developing performance and innovative systems. Gel dosimeters are based on chemical dosimeters in which radiation-induced chemical reactions occur. The addition of gelling agents can enable these chemical reactions to be stabilized spatially, which enables the 3D dose distribution within the volume of the dosimeter to be determined. Despite extensive research over the last three decades, gel dosimeters have yet to achieve widespread clinical acceptance, mainly because of three major practical concerns; toxicity of active materials, oxygen sensitivity of the dose response, and spatial instability of dose information. A number of gel dosimetry systems have been developed over the years with differing mechanisms of operation and varying degrees of success in alleviating the practical issues inhibiting clinical application.

Whereby, this Special Issue invites all researchers and clinicians to publish original research articles, rapid communications, or reviews concerning basic, translational, and clinical research about ionizing radiation dosimetry. Suitable topics include, but are not limited to optimization of dosimetric hydrogel matrices and investigation of physical–chemical mechanisms involved in the dosimetric response.

Dr. Silvia Locarno
Dr. Salvatore Gallo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

21 pages, 17243 KiB  
Article
Microscopic and Macroscopic Characterization of Hydrogels Based on Poly(vinyl-alcohol)–Glutaraldehyde Mixtures for Fricke Gel Dosimetry
by Silvia Locarno, Paolo Arosio, Francesca Curtoni, Marco Piazzoni, Emanuele Pignoli and Salvatore Gallo
Gels 2024, 10(3), 172; https://doi.org/10.3390/gels10030172 - 28 Feb 2024
Viewed by 1013
Abstract
In recent decades, hydrogels have emerged as innovative soft materials with widespread applications in the medical and biomedical fields, including drug delivery, tissue engineering, and gel dosimetry. In this work, a comprehensive study of the macroscopic and microscopic properties of hydrogel matrices based [...] Read more.
In recent decades, hydrogels have emerged as innovative soft materials with widespread applications in the medical and biomedical fields, including drug delivery, tissue engineering, and gel dosimetry. In this work, a comprehensive study of the macroscopic and microscopic properties of hydrogel matrices based on Poly(vinyl-alcohol) (PVA) chemically crosslinked with Glutaraldehyde (GTA) was reported. Five different kinds of PVAs differing in molecular weight and degree of hydrolysis were considered. The local microscopic organization of the hydrogels was studied through the use of the 1H nuclear magnetic resonance relaxometry technique. Various macroscopic properties (gel fraction, water loss, contact angle, swelling degree, viscosity, and Young’s Modulus) were investigated with the aim of finding a correlation between them and the features of the hydrogel matrix. Additionally, an optical characterization was performed on all the hydrogels loaded with Fricke solution to assess their dosimetric behavior. The results obtained indicate that the degree of PVA hydrolysis is a crucial parameter influencing the structure of the hydrogel matrix. This factor should be considered for ensuring stability over time, a vital property in the context of potential biomedical applications where hydrogels act as radiological tissue-equivalent materials. Full article
(This article belongs to the Special Issue Gel Dosimetry (2nd Edition))
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