Dear Colleagues,

Yeast, noted as the pioneering eukaryotic organism to undergo complete genome sequencing, holds the distinction of being the earliest microorganism employed in brewing, food, and various other industries. The utilization of yeast boasts several advantages, including a well-defined genetic background, robust genetic manipulability, and commendable fermentation capabilities. In recent times, the synergy of progressive technologies such as synthetic biology, bioinformatics, and machine learning has propelled the advancement and implementation of metabolic engineering and synthetic biology within this domain. Yeast cell factories have garnered extensive usage in the synthesis of numerous bulk chemicals and innovative, high-value bioactive compounds, thereby achieving noteworthy breakthroughs in domains spanning energy, medicine, and the environment.

The efficiency of yeast as a cell factory platform has significantly improved, finding extensive use in the large-scale production of diverse foods, chemicals, and drugs like ethanol, hemoglobin, terpenoids, and more. Yeast cell factories enable continuous and eco-friendly synthesis of industrial chemicals, offering an alternative to conventional methods. Enhancing yeast's metabolic pathways, key enzymes, strain resilience, and transport mechanisms can boost its performance. Additionally, manipulating yeast organelles and creating synthetic gene routes can enhance pathway enzymes and regulate metabolic flux dynamically. This enhances yeast's role as a versatile bioengineering tool.

The theme of this Special Issue is “Advances in Yeast Biotechnology from Genomics to Industry”. This Special Issue will cover topics related to yeast cell factories, yeast genomics, yeast synthetic biology, yeast metabolic engineering, and yeast cell metabolic models. These studies will help researchers continuously expand the application of synthetic biology, systems biology, and bioinformatics in future yeast cell industrial applications and other fields.

Dr. Chao Ye
Dr. Qiang Ding
Guest Editors

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• yeast synthetic biology
• yeast metabolic engineering
• yeast genomics
• yeast cell factory
• yeast metabolic network model reconstruction
• genetic circuit
• dynamic regulation