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Diagnostics
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Current Concepts and Prospects of Diagnostics in Oral Diseases
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Current Concepts and Prospects of Diagnostics in Oral Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 34690

Special Issue Editors

Dr. Shankargouda Patil

E-Mail Website
Guest Editor
College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA
Interests: oral pathology; oral biology; oral cancer; oral medicine; stem cells
Special Issues, Collections and Topics in MDPI journals
Dr. Dario Di Nardo

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, 00161 Rome, Italy
Interests: endodontics; prosthodontics; CBCT; dental imaging; endodontic surgery; MRI
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral diseases are often diagnosed largely based on clinical oral examination. The correlation of radiographical and pathological findings with clinical manifestations has improved the overall diagnostic accuracy of oral pathologies. Any disease process initiates as a molecular aberration which eventually manifests at a cellular level as evidenced in pathological examination and culminates into a clinical presentation. Thus, for an early diagnosis, identification of the disease process at its incipient molecular stage is imperative. The advent of molecular biology has led to the discovery of a wide array of biomarkers based on biological samples.  Concerning oral diseases, the most common biological samples assessed include saliva, followed by biopsied oral hard and soft tissues, gingival crevicular fluid, biofilm, smear, and blood. The depth of investigation into these biological samples determines the accuracy of diagnosis. In this context, studies have often used a wide range of diagnostic modalities ranging from immunohistochemistry, immunofluorescence, polymerase chain reaction, flow cytometry, proteomics, and genomics to next-generation sequencing. Integration of these molecular techniques with artificial intelligence has been shown to significantly improve the sensitivity and specificity of oral diagnostics. Thus, the present Special Issue is being formulated to collect articles investigating biological samples collected from patients using a wide array of techniques including molecular tools, novel radiographic and pathological modalities, and artificial intelligence to enhance the diagnostic accuracy and to delineate the underlying disease pathogenesis.

Dr. Shankargouda Patil
Dr. Dario Di Nardo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral carcinoma
  • oral potentially malignant disorders
  • oral sarcoma
  • salivary gland cysts and tumors
  • odontogenic cysts and tumors
  • developmental disorders
  • immune-mediated oral diseases
  • oral infectious diseases
  • syndromes with oral manifestations
  • metabolic disorders with oral manifestations
  • saliva
  • gingival crevicular fluid
  • oral mucosa
  • maxilla
  • mandible
  • temperomandibular joint
  • blood
  • radiographic techniques
  • artificial intelligence
  • immunohistochemistry
  • immunofluorescence
  • polymerase chain reaction
  • flow cytometry
  • proteomics
  • genomics
  • next-generation sequencing
  • COVID-19
  • implantology
  • periodontics
  • endodontics
  • prosthodontics
  • pediatric dentistry
  • orthodontics
  • oral surgery

Published Papers (11 papers)

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Editorial

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3 pages, 183 KiB  
Editorial
Innovations in Diagnostic Imaging in Oral and Maxillofacial Diseases
by Maurilio D’Angelo, Alessio Zanza, Dario Di Nardo and Luca Testarelli
Diagnostics 2022, 12(2), 536; https://doi.org/10.3390/diagnostics12020536 - 19 Feb 2022
Viewed by 1382
Abstract
In recent years, improvements in imaging techniques have profoundly facilitated the diagnosis of pathologies of the maxillofacial district [...] Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)

Research

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12 pages, 1251 KiB  
Article
Clinical Utility of Quantitative Parameters of Salivary Gland Scintigraphy for Diagnosing Burning Mouth Syndrome
by Hyung Kwon Byeon, Geum Cheol Jeong, Beomsoo Kim, Yeongrok Lee, Jae Hong Park and Sang Mi Lee
Diagnostics 2022, 12(9), 2256; https://doi.org/10.3390/diagnostics12092256 - 18 Sep 2022
Cited by 1 | Viewed by 1754
Abstract
Burning mouth syndrome (BMS) is a chronic disorder characterized by a burning sensation in the oral cavity, often accompanied by xerostomia, with no relevant clinical or laboratory findings. This study aimed to investigate diagnostic values of quantitative parameters of salivary gland scintigraphy for [...] Read more.
Burning mouth syndrome (BMS) is a chronic disorder characterized by a burning sensation in the oral cavity, often accompanied by xerostomia, with no relevant clinical or laboratory findings. This study aimed to investigate diagnostic values of quantitative parameters of salivary gland scintigraphy for BMS in patients with xerostomia. A total of 164 patients who underwent salivary gland scintigraphy for the workup of xerostomia were retrospectively reviewed. All patients were classified into patient groups with primary BMS, secondary BMS, and non-specific xerostomia. From salivary gland scintigraphy, 22 quantitative parameters were calculated and their diagnostic values were assessed based on the area under the receiver operating characteristic curve (AUC) values. Among salivary gland scintigraphy parameters, uptake speed in the left submandibular gland showed the highest AUC value (0.647) for detecting BMS and pre-stimulatory oral activity showed the highest AUC value (0.710) for detecting primary BMS. A salivary gland scintigraphy scoring system based on these two parameters further enhanced the diagnostic ability, demonstrating AUC values of 0.731 for BMS and 0.782 for primary BMS. These results suggest a potential diagnostic value of the quantitative parameters of salivary gland scintigraphy for detecting BMS in patients with xerostomia. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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12 pages, 276 KiB  
Article
Evaluation and Comparison of Genomic DNA Extraction Methods and PCR Optimization on Archival Formalin-Fixed and Paraffin-Embedded Tissues of Oral Squamous Cell Carcinoma
by Samar Saeed Khan, Manisha Tijare, Sowmya Kasetty, Megha Jain, Ahmed Alamoudi, Hammam Ahmed Bahammam, Sarah Ahmed Bahammam, Maha A. Bahammam, Saranya Varadarajan, A. Thirumal Raj and Shankargouda Patil
Diagnostics 2022, 12(5), 1219; https://doi.org/10.3390/diagnostics12051219 - 12 May 2022
Viewed by 2250
Abstract
Recovery and amplification of nucleic acids from archived formalin-fixed tissue samples is the most developing field in retrospective genetic studies. We compared different deparaffinization methods and DNA isolation techniques, and intergroup comparisons were performed to evaluate the effectiveness of different storing methods for [...] Read more.
Recovery and amplification of nucleic acids from archived formalin-fixed tissue samples is the most developing field in retrospective genetic studies. We compared different deparaffinization methods and DNA isolation techniques, and intergroup comparisons were performed to evaluate the effectiveness of different storing methods for archival OSCC samples based on obtained mean DNA quantity, quality, and PCR amplification of the P53 gene. The study comprised 75 archival histologically diagnosed OSCC samples which were divided into Group I: Formalin-fixed paraffin-embedded tissue blocks and Group II: Long-term formalin-fixed tissue. A comparison of different deparaffinization methods showed that xylene deparaffinization is an efficient method to obtain suitable DNA. Comparing different DNA isolation techniques illustrated that the conventional phenol–chloroform method gives better integrity to DNA in contrast with the kit method. Comparison between FFPET and long-term FFT samples demonstrated that samples fixed in formalin overnight and embedded in wax yield better quality and quantity DNA in comparison with long-term samples fixed in formalin. To obtain suitable integrity of DNA, tissue samples should be stored by fixing in formalin overnight followed by preparation of paraffin tissue blocks, deparaffinization by xylene, and subjecting them to the conventional phenol–chloroform DNA isolation protocol. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
11 pages, 5492 KiB  
Article
Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
by Dominic Augustine, Roopa S. Rao, Lakshminarayana Surendra, Shankargouda Patil, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Sarah Albogami, Shaheen Shamsuddin, Sulphi Abdul Basheer and Shan Sainudeen
Diagnostics 2022, 12(5), 1114; https://doi.org/10.3390/diagnostics12051114 - 29 Apr 2022
Viewed by 2905
Abstract
The histologic properties of tumors seem to affect their biological behavior, and the same holds good for solid multicystic ameloblastoma (SMA), a benign, locally destructive lesion. Hyalinization is one such histological factor that has been demonstrated to correlate with the biological behavior of [...] Read more.
The histologic properties of tumors seem to affect their biological behavior, and the same holds good for solid multicystic ameloblastoma (SMA), a benign, locally destructive lesion. Hyalinization is one such histological factor that has been demonstrated to correlate with the biological behavior of neoplasms. The present study aimed to analyze the correlation between the severity of hyalinization (SOH) and the recurrence potential of SMAs. The study was performed on formalin-fixed, paraffin-embedded (FFPE) diagnosed archival cases of SMA, follicular SMA (n = 35) and plexiform SMA (n = 25). The cases were evaluated for SOH and scored from 0–3, and the correlation between SOH and recurrence was analyzed for statistical significance. The clinical parameters of the lesion were analyzed for statistical correlation with recurrence. The SOH significantly correlated with the recurrence of SMA (p = 0.001). The histologic type did not influence the biological behavior of SMA. The location of SMA in the body of the mandible (p = 0.036), multilocular radiolucency (p = 0.001) and root resorption (p = 0.002) also showed strong statistical correlation with recurrence. It is evident from the present study that hyalinization strongly correlates with the biological behavior of SMA. Future studies with advanced investigations could validate the presence of hyalinization and identify the origin of the hyalinized product in SMAs. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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9 pages, 4519 KiB  
Article
Subepithelial Hyalinisation Predicts Recurrence of Unicystic Ameloblastomas
by Dominic Augustine, Roopa S. Rao, Lakshminarayana Surendra, Bharti Gupta, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Pradeep Kumar Yadalam, Shazia Mushtaq, Zeeshan Hera Ahmed and Shankargouda Patil
Diagnostics 2022, 12(3), 756; https://doi.org/10.3390/diagnostics12030756 - 20 Mar 2022
Viewed by 1976
Abstract
The inductive effect of hyalinisation and its influence on the biologic behaviour of ameloblastoma variants represent a scarcely researched domain of oral pathology. The complexity of the induction effects within the odontogenic apparatus, with the involvement of both ectodermal and mesodermal tissues, is [...] Read more.
The inductive effect of hyalinisation and its influence on the biologic behaviour of ameloblastoma variants represent a scarcely researched domain of oral pathology. The complexity of the induction effects within the odontogenic apparatus, with the involvement of both ectodermal and mesodermal tissues, is responsible for diverse histopathological characteristics, hyalinisation being the major feature. The present study aims to deduce for the first time the correlation between the severity of hyalinisation (SOH) and recurrence in three unicystic ameloblastoma (UA) variants, namely, intra-luminal (UA-IL), luminal (UA-L) and mural (UA-M). Retrospectively diagnosed archival cases of UA-IL (n = 08), UA-L (n = 22) and UA-M (n = 30) were assessed for SOH and its correlation with recurrence. A subgroup comparison (between UA-IL/UA-L and UA-M) was also performed. The clinical parameters of the patients were also analysed from files for clinicopathological correlation with recurrence. Results: sub-epithelial hyalinisation (SEH) significantly correlated with the recurrence of UA-L and UA-M (p = 0.001). When the histologic types (UA-L and UA-IL vs. UA-M) were grouped and the correlation of SOH with recurrence was checked, it was observed that both groups (p = 0.001) showed strong statistical correlation. UA-M lesions with multilocular radiolucency (p = 0.001) also showed significant correlation with recurrence. SOH can be a reliable histological predictor of recurrence and of aggressive biologic behaviour in UA. The present study shows a significant association of hyalinisation with the biologic behaviour of UA. Further studies with immunohistochemical investigations could validate the presence of hyalinisation and identify the origin of the hyalinised product in UAs. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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Review

Jump to: Editorial, Research, Other

11 pages, 834 KiB  
Review
Exploring an Association between Body Mass Index and Oral Health—A Scoping Review
by Rakhi Issrani, Jagat Reddy, Alzarea K. Bader, Raghad Fayez H. Albalawi, Ebtehal Dhyab M. Alserhani, Danah Sultan R. Alruwaili, Gharam Radhi A. Alanazi, Naif Sultan R. Alruwaili, Mohammed Ghazi Sghaireen and Krishna Rao
Diagnostics 2023, 13(5), 902; https://doi.org/10.3390/diagnostics13050902 - 27 Feb 2023
Cited by 7 | Viewed by 1561
Abstract
Background: Basal metabolic index (BMI) is a unique anthropometric indicator used to define the relative amount of body fat on an individual’s frame. There are many diseases and conditions associated with obesity and underweight. Recent research trials suggest that there is a significant [...] Read more.
Background: Basal metabolic index (BMI) is a unique anthropometric indicator used to define the relative amount of body fat on an individual’s frame. There are many diseases and conditions associated with obesity and underweight. Recent research trials suggest that there is a significant association between oral health indicators and BMI as both are attributed to common risk factors such as dietary, genetic, socioeconomic, and lifestyle issues. Objectives: The main objective of this review paper is to emphasize the association between BMI and oral health with available literature evidence. Methodology: A literature search was conducted using multiple databases comprising of MEDLINE (via PubMed), EMBASE, and Web of Science. The terms used for the search were “body mass index”, “periodontitis”, “dental caries”, and “tooth loss”. Results: In total, 2839 articles were obtained from the analysis of the databases. Unrelated articles from the available full text of 1135 articles were excluded. The main reasons for excluding the articles were: they were dietary guidelines and policy statements. A total of 66 studies were finally included in the review. Conclusion: The presence of dental caries, periodontitis and tooth loss may be associated with a higher BMI or obesity, whereas, improved oral health might be associated with lower BMI. Promoting general and oral health should be a hand in hand feature, as common risk factors can be embattled. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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11 pages, 1224 KiB  
Review
Recent Advances in the Diagnosis of Enamel Cracks: A Narrative Review
by Bassam Zidane
Diagnostics 2022, 12(8), 2027; https://doi.org/10.3390/diagnostics12082027 - 22 Aug 2022
Cited by 5 | Viewed by 6797
Abstract
Cracked teeth can pose a diagnostic dilemma for a clinician as they can mimic several other conditions. The constant physiological stress along with any pathological strain like trauma or iatrogenic causes can lead to the development of microcracks in the teeth. Constant exposure [...] Read more.
Cracked teeth can pose a diagnostic dilemma for a clinician as they can mimic several other conditions. The constant physiological stress along with any pathological strain like trauma or iatrogenic causes can lead to the development of microcracks in the teeth. Constant exposure to immense stress can cause the progression of these often-undiagnosed tooth cracks to cause tooth fractures. This review aims to outline the etiology of tooth cracks, their classification, and recent advances in the diagnosis of enamel cracks. Diagnosing a cracked tooth can be an arduous task as symptoms differ according to the location and extension of the incomplete fracture. Early detection is critical because restorative treatment can prevent fracture propagation, microleakage, pulpal or periodontal tissue involvement, and catastrophic cusp failure. Older methods of crack detection are not sensitive or specific. They include clinical examination, visual inspection, exploratory excavation, and percussion test. The dye test used blue or gentian violet stains to highlight fracture lines. Modern methods include transillumination, optical coherence tomography Swept-Source Optical Coherence Tomography (SSOCT), near-infrared imaging, ultrasonic system, infrared thermography, and near-infrared laser. These methods appear to be more efficacious than traditional clinical dental imaging techniques in detecting longitudinal tooth cracks. Clinically distinguishing between the various types of cracks can be difficult with patient-reported signs and symptoms varying according to the location and extension of the incomplete fracture. Cracks are more common in restored teeth. Technological advances such as transillumination allow for early detection and enhanced prognosis. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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14 pages, 692 KiB  
Review
Artificial Intelligence in the Diagnosis of Oral Diseases: Applications and Pitfalls
by Shankargouda Patil, Sarah Albogami, Jagadish Hosmani, Sheetal Mujoo, Mona Awad Kamil, Manawar Ahmad Mansour, Hina Naim Abdul, Shilpa Bhandi and Shiek S. S. J. Ahmed
Diagnostics 2022, 12(5), 1029; https://doi.org/10.3390/diagnostics12051029 - 19 Apr 2022
Cited by 32 | Viewed by 7336
Abstract
Background: Machine learning (ML) is a key component of artificial intelligence (AI). The terms machine learning, artificial intelligence, and deep learning are erroneously used interchangeably as they appear as monolithic nebulous entities. This technology offers immense possibilities and opportunities to advance diagnostics in [...] Read more.
Background: Machine learning (ML) is a key component of artificial intelligence (AI). The terms machine learning, artificial intelligence, and deep learning are erroneously used interchangeably as they appear as monolithic nebulous entities. This technology offers immense possibilities and opportunities to advance diagnostics in the field of medicine and dentistry. This necessitates a deep understanding of AI and its essential components, such as machine learning (ML), artificial neural networks (ANN), and deep learning (DP). Aim: This review aims to enlighten clinicians regarding AI and its applications in the diagnosis of oral diseases, along with the prospects and challenges involved. Review results: AI has been used in the diagnosis of various oral diseases, such as dental caries, maxillary sinus diseases, periodontal diseases, salivary gland diseases, TMJ disorders, and oral cancer through clinical data and diagnostic images. Larger data sets would enable AI to predict the occurrence of precancerous conditions. They can aid in population-wide surveillance and decide on referrals to specialists. AI can efficiently detect microfeatures beyond the human eye and augment its predictive power in critical diagnosis. Conclusion: Although studies have recognized the benefit of AI, the use of artificial intelligence and machine learning has not been integrated into routine dentistry. AI is still in the research phase. The coming decade will see immense changes in diagnosis and healthcare built on the back of this research. Clinical significance: This paper reviews the various applications of AI in dentistry and illuminates the shortcomings faced while dealing with AI research and suggests ways to tackle them. Overcoming these pitfalls will aid in integrating AI seamlessly into dentistry. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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12 pages, 1128 KiB  
Review
Host Defence Peptides in Diabetes Mellitus Type 2 Patients with Periodontal Disease. A Systematic Review
by Muhammad Saad Shaikh, Muhammad Sohail Zafar, Farhan Saleem, Ahmad Alnazzawi, Mohid Abrar Lone, Syed Jawad Ali Bukhari and Zohaib Khurshid
Diagnostics 2021, 11(12), 2210; https://doi.org/10.3390/diagnostics11122210 - 26 Nov 2021
Cited by 2 | Viewed by 1945
Abstract
The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific [...] Read more.
The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case-control, 6 cross-sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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Other

21 pages, 2812 KiB  
Systematic Review
Oral Warty Dyskeratoma—A Systematic Review of the Literature
by A. Thirumal Raj, Kamran Habib Awan, Shankargouda Patil, Peter Morgan and Saman Warnakulasuriya
Diagnostics 2022, 12(5), 1273; https://doi.org/10.3390/diagnostics12051273 - 20 May 2022
Cited by 1 | Viewed by 2499
Abstract
Objective: To systematically review the clinicopathological features of oral warty keratoma based on published literature. Materials and Methods: PubMed and Scopus databases were searched for reports of oral warty dyskeratoma. Of the 52 identified articles, only 25 articles (43 cases) satisfied the selection [...] Read more.
Objective: To systematically review the clinicopathological features of oral warty keratoma based on published literature. Materials and Methods: PubMed and Scopus databases were searched for reports of oral warty dyskeratoma. Of the 52 identified articles, only 25 articles (43 cases) satisfied the selection criteria (case report/series in the English language reporting clinicopathologically diagnosed oral warty dyskeratoma/oral focal acantholytic keratosis/oral isolated dyskeratosis follicularis in humans). Risk of bias was assessed using the Joanna Briggs institute critical appraisal checklist for case reports and case series. Results: Most cases had well-circumscribed, white, nodular verruco-papillary lesions with a central depressed/crater-like area. Alveolar ridges were the most frequent sites of occurrence and tobacco was the most commonly associated risk factor. Histopathologically, the most pathognomonic feature was the supra-basal clefting. The cleft had dyskeratotic acantholytic cells (corps ronds, and grains). Below the cleft were projections of the connective tissue villi lined by basal cells. The basal cells in a few cases exhibited hyperplasia in the form of budding into the stroma, but epithelial dysplasia was not reported. The surface epithelium had crypts filled with keratin debris. Conclusion: Oral warty dyskeratoma is a rare solitary self-limiting benign entity, which due to its clinical and histopathological resemblance and associated habit history could be misdiagnosed as leukoplakia or carcinoma. None of the assessed articles provided molecular data, which in turn could be the reason for the lack of insight into the etiopathogenesis of this enigmatic lesion. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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6 pages, 1629 KiB  
Case Report
An Extremely Rare Case of Sebaceous Adenoma Involving the Parotid Gland
by Octavian Marius Dincă, Mihai Bogdan Bucur, George Cristian Vlădan, Valentin Nicolae Varlas and Alexandru Bucur
Diagnostics 2022, 12(5), 1232; https://doi.org/10.3390/diagnostics12051232 - 14 May 2022
Viewed by 2009
Abstract
Sebaceous adenoma is an extremely rare tumor located in the parotid gland. In the English literature, less than 10 cases have been reported. Sebaceous adenoma represents 0.5% of all monomorphic adenomas. The authors are presenting a case of sebaceous adenoma of the parotid [...] Read more.
Sebaceous adenoma is an extremely rare tumor located in the parotid gland. In the English literature, less than 10 cases have been reported. Sebaceous adenoma represents 0.5% of all monomorphic adenomas. The authors are presenting a case of sebaceous adenoma of the parotid gland in a 65-year-old female who presented a mass on the left parotid area that had been gradually enlarging for one year without symptoms of pain. On imaging (ultrasound), a well-defined mass lesion in the left parotid area was seen. Histopathological findings were consistent with sebaceous adenoma. Surgical excision is curative. The prognosis is excellent, with a low recurrence rate. The present case report will increase the awareness and possibility of this rare tumor occurring at an unusual site, thereby avoiding any chance of misdiagnosis. Full article
(This article belongs to the Special Issue Current Concepts and Prospects of Diagnostics in Oral Diseases)
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