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Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology...
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Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology and Translational Medicine

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".

Deadline for manuscript submissions: closed (20 October 2021) | Viewed by 27165

Special Issue Editor

Prof. Dr. Domenico Tricarico

E-Mail Website
Guest Editor
Section of Pharmacology, Department of Pharmacy-Pharmaceutical Sciences, University of Bari, Via Orabona 4, 70125 Bari, Italy
Interests: bone; cell cycle; akt; Ca2+-activated K+(BK) channel; calcium ions; cell volume; trp channels; KATP and Kir channels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The proposed Issue is focused on novel pathways involved in the regulation of the cell cycle and proliferation in animal cells. Emerging factors regulating cell proliferation are of interest at this time. The gene encoding for growth factors and cytosolic and membrane proteins may affect the cell cycle inhibiting proliferation or inducing proliferation. Ion channel subunits and transporters, for instance, are some of the latest factors that were demonstrated to be capable of regulating the cell cycle and proliferation. The novel role of kinases and enzymes of the inflammatory cascades that can be targeted regulating cell proliferation is also of interest. The collected “in vitro” data should have translational significance when validated in animal models of diseases, especially cancers and inflammatory based-diseases, or in robust “in vitro” models of diseases. The signaling pathway hypothesis and the mechanism regulating proliferation in normal and disease conditions need to be discovered. We do not include papers related to the epidemiology of disease at this time.

Prof. Dr. Domenico Tricarico
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Ion channel subunits, transporters
  • Enzymes and intracellular targets
  • Cell cycle and proliferation
  • Growth factors, cytokines
  • “In vitro” or “in vivo” model of disease.

Published Papers (6 papers)

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Research

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15 pages, 3395 KiB  
Article
The Effect of the Clenbuterol—β2-Adrenergic Receptor Agonist on the Peripheral Blood Mononuclear Cells Proliferation, Phenotype, Functions, and Reactive Oxygen Species Production in Race Horses In Vitro
by Olga Witkowska-Piłaszewicz, Rafał Pingwara, Jarosław Szczepaniak and Anna Winnicka
Cells 2021, 10(4), 936; https://doi.org/10.3390/cells10040936 - 17 Apr 2021
Cited by 2 | Viewed by 4202
Abstract
Clenbuterol, the β2-adrenoceptor agonist, is gaining growing popularity because of its effects on weight loss (i.e., chemical liposuction). It is also popular in bodybuilding and professional sports, due to its effects that are similar to anabolic steroids. However, it is prohibited by anti-doping [...] Read more.
Clenbuterol, the β2-adrenoceptor agonist, is gaining growing popularity because of its effects on weight loss (i.e., chemical liposuction). It is also popular in bodybuilding and professional sports, due to its effects that are similar to anabolic steroids. However, it is prohibited by anti-doping control. On the other hand, it is suggested that clenbuterol can inhibit the inflammatory process. The cells from 14 untrained and 14 well-trained race horses were collected after acute exercise and cultured with clenbuterol. The expressions of CD4, CD8, FoxP3, CD14, MHCII, and CD5 in PBMC, and reactive oxygen species (ROS) production, as well as cell proliferation, were evaluated by flow cytometry. In addition, IL-1β, IL-4, IL-6, IL-10, IL-17, INF-γ and TNF-α concentrations were evaluated by ELISA. β2-adrenoceptor stimulation leads to enhanced anti-inflammatory properties in well-trained horses, as do low doses in untrained animals. In contrast, higher clenbuterol doses create a pro-inflammatory environment in inexperienced horses. In conclusion, β2-adrenoceptor stimulation leads to a biphasic response. In addition, the immune cells are more sensitive to drug abuse in inexperienced individuals under physical training. Full article
(This article belongs to the Special Issue Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology and Translational Medicine)
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13 pages, 8176 KiB  
Article
Microvascular Density, Endothelial Area, and Ki-67 Proliferative Index Correlate Each Other in Cat Post-Injection Fibrosarcoma
by Rosa Patruno, Giuseppe Passantino, Carmelo Laface, Antonella Tinelli, Alfredo Zito, Roberta Ruggieri, Francesco Luposella, Pietro Gadaleta, Mariarita Laforgia, Luca Lacitignola, Michele Ammendola, Girolamo Ranieri and Nicola Zizzo
Cells 2021, 10(1), 31; https://doi.org/10.3390/cells10010031 - 28 Dec 2020
Cited by 9 | Viewed by 3174
Abstract
Soft tissue sarcomas are a large group of different tumor types both in humans and in animals. Among them, fibrosarcoma is the most frequent malignant mesenchymal tumoral form in cats, representing up to 28% of all cat skin tumors, while human fibrosarcoma, fortunately, [...] Read more.
Soft tissue sarcomas are a large group of different tumor types both in humans and in animals. Among them, fibrosarcoma is the most frequent malignant mesenchymal tumoral form in cats, representing up to 28% of all cat skin tumors, while human fibrosarcoma, fortunately, only represents 5% of all sarcomas and 0.025% of the world-wide burden of tumors. This low incidence in humans leads to consideration of this group of tumoral diseases as rare, so therapeutic options are few due to the difficulty of starting clinical trials. In this context, the identification of research models for fibrosarcomas could be of great interest to deepen knowledge in this field and recognize new or possible biological pathways involved in tumor progression and metastasis. Angiogenesis is considered a fundamental scattering cause of tumor aggressiveness and progression in all forms of cancer, but only a few research parameters were developed and reported to express them quantitatively and qualitatively. The role in angiogenesis of microenvironmental stromal cells, such as fibroblasts, lymphocytes, mast cells, and macrophages, was largely demonstrated since this topic was first approached, while quantification of new vessels and their blood capacity in tumoral area is a relatively recent approach that could be well developed thanks to expertise in immunohistochemistry and image analysis. In this paper, a crossing study evaluating microvascular density (MVD), endothelial area (EA), and Ki-67 proliferative index was reported for a series of formalin-fixed and paraffin-embedded tissue samples from 99 cat patients, affected by cat post-injection fibrosarcoma, by using a till ×400 magnification light microscopy. We aim to demonstrate that cat pets may be considered a useful animal model for better studying the correspondent human diseases and we report, for the first time to our knowledge, experimental data in terms of correlation among MVD, EA, and Ki-67 strictly involved in aggressiveness and tumoral progression. Full article
(This article belongs to the Special Issue Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology and Translational Medicine)
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Review

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20 pages, 1168 KiB  
Review
Folic Acid and Autism: A Systematic Review of the Current State of Knowledge
by Bianka Hoxha, Malvina Hoxha, Elisa Domi, Jacopo Gervasoni, Silvia Persichilli, Visar Malaj and Bruno Zappacosta
Cells 2021, 10(8), 1976; https://doi.org/10.3390/cells10081976 - 03 Aug 2021
Cited by 20 | Viewed by 6697
Abstract
Folic acid has been identified to be integral in rapid tissue growth and cell division during fetal development. Different studies indicate folic acid’s importance in improving childhood behavioral outcomes and underline its role as a modifiable risk factor for autism spectrum disorders. The [...] Read more.
Folic acid has been identified to be integral in rapid tissue growth and cell division during fetal development. Different studies indicate folic acid’s importance in improving childhood behavioral outcomes and underline its role as a modifiable risk factor for autism spectrum disorders. The aim of this systematic review is to both elucidate the potential role of folic acid in autism spectrum disorders and to investigate the mechanisms involved. Studies have pointed out a potential beneficial effect of prenatal folic acid maternal supplementation (600 µg) on the risk of autism spectrum disorder onset, but opposite results have been reported as well. Folic acid and/or folinic acid supplementation in autism spectrum disorder diagnosed children has led to improvements, both in some neurologic and behavioral symptoms and in the concentration of one-carbon metabolites. Several authors report an increased frequency of serum auto-antibodies against folate receptor alpha (FRAA) in autism spectrum disorder children. Furthermore, methylene tetrahydrofolate reductase (MTHFR) polymorphisms showed a significant influence on ASD risk. More clinical trials, with a clear study design, with larger sample sizes and longer observation periods are necessary to be carried out to better evaluate the potential protective role of folic acid in autism spectrum disorder risk. Full article
(This article belongs to the Special Issue Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology and Translational Medicine)
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21 pages, 1577 KiB  
Review
Epigenetically Mediated Ciliogenesis and Cell Cycle Regulation, and Their Translational Potential
by Linda Xiaoyan Li and Xiaogang Li
Cells 2021, 10(7), 1662; https://doi.org/10.3390/cells10071662 - 02 Jul 2021
Cited by 4 | Viewed by 4800
Abstract
Primary cilia biogenesis has been closely associated with cell cycle progression. Cilia assemble when cells exit the cell cycle and enter a quiescent stage at the post-mitosis phase, and disassemble before cells re-enter a new cell cycle. Studies have focused on how the [...] Read more.
Primary cilia biogenesis has been closely associated with cell cycle progression. Cilia assemble when cells exit the cell cycle and enter a quiescent stage at the post-mitosis phase, and disassemble before cells re-enter a new cell cycle. Studies have focused on how the cell cycle coordinates with the cilia assembly/disassembly process, and whether and how cilia biogenesis affects the cell cycle. Appropriate regulation of the functions and/or expressions of ciliary and cell-cycle-associated proteins is pivotal to maintaining bodily homeostasis. Epigenetic mechanisms, including DNA methylation and histone/chromatin modifications, are involved in the regulation of cell cycle progression and cilia biogenesis. In this review, first, we discuss how epigenetic mechanisms regulate cell cycle progression and cilia biogenesis through the regulation of DNA methylation and chromatin structures, to either promote or repress the transcription of genes associated with those processes and the modification of cytoskeleton network, including microtubule and actin. Next, we discuss the crosstalk between the cell cycle and ciliogenesis, and the involvement of epigenetic regulators in this process. In addition, we discuss cilia-dependent signaling pathways in cell cycle regulation. Understanding the mechanisms of how epigenetic regulators contribute to abnormal cell cycle regulation and ciliogenesis defects would lead to developing therapeutic strategies for the treatment of a wide variety of diseases, such as cancers, polycystic kidney disease (PKD), and other ciliopathy-associated disorders. Full article
(This article belongs to the Special Issue Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology and Translational Medicine)
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20 pages, 4605 KiB  
Review
DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy
by Lu Zhang and Xiaogang Li
Cells 2021, 10(6), 1540; https://doi.org/10.3390/cells10061540 - 18 Jun 2021
Cited by 23 | Viewed by 4832
Abstract
Cell cycle is regulated through numerous signaling pathways that determine whether cells will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle regulation has been linked to many diseases. Thus, there is an urgent need to understand the diverse molecular mechanisms of [...] Read more.
Cell cycle is regulated through numerous signaling pathways that determine whether cells will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle regulation has been linked to many diseases. Thus, there is an urgent need to understand the diverse molecular mechanisms of how the cell cycle is controlled. RNA helicases constitute a large family of proteins with functions in all aspects of RNA metabolism, including unwinding or annealing of RNA molecules to regulate pre-mRNA, rRNA and miRNA processing, clamping protein complexes on RNA, or remodeling ribonucleoprotein complexes, to regulate gene expression. RNA helicases also regulate the activity of specific proteins through direct interaction. Abnormal expression of RNA helicases has been associated with different diseases, including cancer, neurological disorders, aging, and autosomal dominant polycystic kidney disease (ADPKD) via regulation of a diverse range of cellular processes such as cell proliferation, cell cycle arrest, and apoptosis. Recent studies showed that RNA helicases participate in the regulation of the cell cycle progression at each cell cycle phase, including G1-S transition, S phase, G2-M transition, mitosis, and cytokinesis. In this review, we discuss the essential roles and mechanisms of RNA helicases in the regulation of the cell cycle at different phases. For that, RNA helicases provide a rich source of targets for the development of therapeutic or prophylactic drugs. We also discuss the different targeting strategies against RNA helicases, the different types of compounds explored, the proposed inhibitory mechanisms of the compounds on specific RNA helicases, and the therapeutic potential of these compounds in the treatment of various disorders. Full article
(This article belongs to the Special Issue Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology and Translational Medicine)
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Other

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28 pages, 1172 KiB  
Systematic Review
A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
by Elisa Domi, Malvina Hoxha, Emanuela Prendi and Bruno Zappacosta
Cells 2021, 10(6), 1380; https://doi.org/10.3390/cells10061380 - 03 Jun 2021
Cited by 3 | Viewed by 2537
Abstract
Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new [...] Read more.
Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting. Full article
(This article belongs to the Special Issue Novel Insight into Cell Cycle and Proliferation: Impact on Pathophysiology and Translational Medicine)
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