Neuroinflammation Linked to Metabolic Disorders

Dear Colleagues,

Neuroinflammation is considered as a potential causal factor for several brain-related diseases including neurodegenerative diseases. Indeed, the augmentation of pro-inflammatory cytokines is linked to many neurodegenerative pathways including Alzheimer’s disease and Parkinson’s disease that are associated with depression and dementia. Besides, neuroinflammation is also linked to metabolic disorders.  The association between neuroinflammation and metabolic disorders is complex. Indeed, neuroinflammation could be caused by peripheral metabolic deregulations that in turn will induce and aggravate these metabolic disorders. Metabolic disorders also named metabolic syndrome include diabetes and obesity are generally associated with low-grade inflammation. Neuroinflammation related to obesity has been considered to preferentially target the hypothalamus, but however, more recent studies reported that obesity-derived neuroinflammation could affect other brain areas such as the hippocampus, cortex, brainstream, or amygdala. It is noteworthy that metabolic disorders such as insulin resistance and obesity are also linked to neurodegenerative diseases most likely through neuroinflammatory mechanisms. More recent data revealed that inappropriate diets such as high-fat diets increased hypothalamic neuroinflammation prior to any peripheral inflammation suggesting that hypothalamic neuroinflammation could be the initiator of overall inflammation in response to high-fat diets. The cellular and molecular mechanisms linking neuroinflammation to the onset of metabolic disorders are still poorly documented, especially the cross-talk between microglia and neurons/astrocytes/tanycytes, as well as the implicated signaling pathways.

The current special issue will accept original studies, reviews, and technical reports in the field of neuroinflammation with a special focus on neuroinflammation related to metabolic disorders covering from molecular/cellular aspects to more integrative approaches.

Prof. Dr. Mohammed Taouis
Guest Editor

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• Neuroinflammation
• hypothalamus
• brain
• obesity
• insulin resistance
• signaling
• cytokines
• metabolic disorders