Experimental Models in the Molecular and Genomic Characterization of Hepatocellular Carcinoma
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 3671
Special Issue Editor
Interests: circularRNAs; microRNAs; m6A epitrancriptome; extracellular vesicles in inter-cellular communication; EVs as circulating biomarkers; chronic liver diseases; hepatocellular carcinoma
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) accounts for over 90% of primary liver tumors and has become the fifth most common cancer in the world. While improved treatment options have led to a reduction in mortality of distinct malignant tumors, the incidence of HCC is still almost equal to its mortality rate. Even in medically developed countries, patients with advanced hepatocellular carcinoma face overall 1-year and 5-year survival rates of less than 50% and 10%, respectively. In contrast, patients with HCC that is detected at a very early stage have a high probability of successful curative treatment and can achieve overall 5-year survival rates of up to 75%. Hepatocellular carcinoma is characterized by a wide inter- and intratumor heterogeneity, and this molecular heterogeneity contributes to the high risk of cancer recurrence following resection and potentially contributes to primary and secondary resistance to systemic targeted therapies. Therefore, in order to improve treatment and prevention, a more comprehensive genetic and mechanistic understanding of HCC is urgently needed.
With the aim of gathering new ideas and starting novel lines of discussion among researchers, the journal Cells is launching a Special Issue entitled “Experimental Models in the Molecular and Genomic Characterization of Hepatocellular Carcinoma”. Our goal is to collect original research articles and in-depth reviews that present or discuss the application of innovative experimental models for the comprehensive characterization of hepatocellular carcinoma.
Dr. Mirco CastoldiGuest Editor
Manuscript Submission Information
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Keywords
- Hepatocellular carcinoma
- RNA methylation
- Precision cut liver slices (PCLS)
- Circulating nucleic acids
- Liver organoids
