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Cells
Special Issues
HPV-Associated Malignancies: Screening, Prevention and Treatment
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HPV-Associated Malignancies: Screening, Prevention and Treatment

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (1 February 2020) | Viewed by 27249

Special Issue Editor

Dr. Santanu Dasgupta

E-Mail Website
Guest Editor
Department of Medicine, The University of Texas Health North East MD Anderson Cancer Center, 11937 US Hwy 271, Tyler, TX 75708, USA
Interests: cancer; mitochondria; biomarker; exosomes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

High-risk human papilloma virus (hrHPV) infection and associated malignancies are alarmingly increasing worldwide and the United States, particularly in young men and women. Emerging studies have identified many subtypes of HPV in addition to HPV-16 and HPV-18, which can potentially drive cellular transformation leading to malignancy. In this Special Issue, we invite articles covering various aspects of HPV-associated cancers, their current screening, prevention, and therapeutic strategies. Any relevant model systems developed to examine hrHPV-associated carcinomas are also welcome.

Dr. Santanu Dasgupta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human papilloma virus
  • human cancer
  • HPV screening and vaccination
  • prevention and treatment

Published Papers (2 papers)

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Review

14 pages, 563 KiB  
Review
Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma
by Katherine C. Wai, Madeleine P. Strohl, Annemieke van Zante and Patrick K. Ha
Cells 2020, 9(2), 500; https://doi.org/10.3390/cells9020500 - 22 Feb 2020
Cited by 20 | Viewed by 5207
Abstract
The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV– tumors represent two unique biological and clinical entities with different treatment strategies. High-risk [...] Read more.
The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV– tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode oncoproteins E6 and E7 that disrupt cellular senescence and ultimately drive tumorigenesis. Current methods for detection of HPV take advantage of this established oncogenic pathway and detect HPV at various biological stages. This review article provides an overview of the existing technologies employed for the detection of HPV and their current or potential future role in management and prognostication. Full article
(This article belongs to the Special Issue HPV-Associated Malignancies: Screening, Prevention and Treatment)
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12 pages, 794 KiB  
Review
Human Papilloma Virus-Associated Cervical Cancer and Health Disparities
by Patti Olusola, Hirendra Nath Banerjee, Julie V. Philley and Santanu Dasgupta
Cells 2019, 8(6), 622; https://doi.org/10.3390/cells8060622 - 21 Jun 2019
Cited by 200 | Viewed by 21553
Abstract
Cervical cancer develops through persistent infection with high-risk human papilloma virus (hrHPV) and is a leading cause of death among women worldwide and in the United States. Periodic surveillance through hrHPV and Pap smear-based testing has remarkably reduced cervical cancer incidence worldwide and [...] Read more.
Cervical cancer develops through persistent infection with high-risk human papilloma virus (hrHPV) and is a leading cause of death among women worldwide and in the United States. Periodic surveillance through hrHPV and Pap smear-based testing has remarkably reduced cervical cancer incidence worldwide and in the USA. However, considerable discordance in the occurrence and outcome of cervical cancer in various populations exists. Lack of adequate health insurance appears to act as a major socioeconomic burden for obtaining cervical cancer preventive screening in a timely manner, which results in disparate cervical cancer incidence. On the other hand, cervical cancer is aggressive and often detected in advanced stages, including African American and Hispanic/Latina women. In this context, our knowledge of the underlying molecular mechanism and genetic basis behind the disparate cervical cancer outcome is limited. In this review, we shed light on our current understanding and knowledge of racially disparate outcomes in cervical cancer. Full article
(This article belongs to the Special Issue HPV-Associated Malignancies: Screening, Prevention and Treatment)
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