Special Issue "Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities"
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1910
2. Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA
Interests: mechanisms of transcription and replication in chromatin; mechanisms of histone chaperone action in chromatin
Special Issues, Collections and Topics in MDPI journals
In eukaryotic cells, DNA damage occurs in chromatin, a DNA–protein complex that strongly compacts DNA. The packaging of DNA in chromatin creates a strong barrier against DNA-damage-response proteins that must interact with DNA to prevent mutations and cell death. Therefore, during DNA repair, chromatin’s structure is extensively and reversibly modified by factors such as chromatin remodelers, histone variants, and histone post-translational modifications ensure access of the regulatory proteins and DNA repair machinery to their DNA targets. The epigenetic factors that modulate the chromatin environment strongly contribute to an efficient DNA damage response. This highly dynamic process of DNA repair in the chromatin environment is essential for the functioning and survival of the cell. Recent studies have revealed a multitude of factors participating in DNA repair; however, researchers have not yet fully established their mechanisms of action, interacting partners, and roles in the regulation of cellular metabolism and the development of human diseases.
In this Special Issue of Cells, we invite researchers to present original studies and state-of-the-art reviews on the mechanisms and regulation of DNA repair in a chromatin environment, and to discuss their data and opinions.
Prof. Dr. Vasily M. Studitsky
Manuscript Submission Information
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- DNA damage
- DNA repair