Special Issue "Assays to Monitor Autophagy in Model Systems"
Deadline for manuscript submissions: closed (31 May 2017) | Viewed by 126210
Interests: autophagy; endosomal traffic; infection; yeast; virus; subversion
2. Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, H-1117 Budapest, Hungary
Interests: autophagy; Drosophila; endocytosis; lysosome
Autophagy is a cellular process highly conserved among all eukaryotes, which allows the bulk or specific lysosomal degradation of protein complexes or aggregates, organelles and invading pathogens. In the main pathway, the structure(s) targeted for destruction are sequestered into double-membrane vesicles called autophagosomes. Autophagy is involved in a multitude of cellular and organismal functions, including adaptation to starvation, cell differentiation and development, turnover of aberrant structures, lifespan extension, immunity, and type II programmed cell death. This pathway also plays a relevant role in the pathophysiology of neurodegenerative, cardiovascular, chronic inflammatory, muscular and autoimmune diseases, and some malignancies. Crucially, data from model organisms point to modulation of autophagy as an effective therapy to prevent or cure diseases, including certain tumour types, muscular dystrophies and neurodegenerative disorders. For the benefit of human health, it is, thus, vital to further understand the regulation and contribution of this pathway in the different physiological and pathological situations. Obvious targets for therapy are the core components of the autophagy machinery, and consequently it is also of primary importance to determine their molecular function.
The aim of this Special Issue is to provide an overview of the assays frequently employed in model organisms and in vitro mammalian systems that have extensively been used to study the regulation, mechanisms and functions of autophagy. We hope that the techniques presented by expert laboratories will be a valuable practical support for the community of researchers investigating autophagy in diverse contexts and for different purposes.
Prof. Dr. Fulvio Reggiori
Prof. Dr. Gabor Juhasz
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- model organism
- ex vivo
- in vivo