The Role of ROS in Atherosclerosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 132
Special Issue Editor
Interests: molecular and genetic determinants of atherosclerosis; cardiometabolic disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Atherosclerosis is a chronic inflammatory disease characterized by the buildup of fatty substances in the arterial walls, leading to heart attack, ischemic stroke, and gangrene. Despite optimal treatment with drugs to alleviate hypercholesterolemia, hypertension and type 2 diabetes, and prevent thrombotic complications, this disease continues to be the leading cause of death globally. Therefore, there is an urgent need for understanding the pathogenesis of atherosclerosis and finding more effective prevention and treatment strategies. Reactive oxygen/nitrogen species (ROS) are reactive intermediates of oxygen and nitrogen produced from various metabolic processes in various cells and are involved in essential biological processes. Oxidative stress resulting from an increased production of ROS and/or reduced antioxidant capacity is an important mechanism underlying the pathogenesis of many common diseases, including atherosclerosis. Traditional risk factors of atherosclerosis, such as dyslipidemia, hypertension, obesity, type 2 diabetes, smoking, and ageing, are major drivers of oxidative stress. There is considerable interest in the utilization of antioxidant molecules to treat atherosclerosis. In this Special Issue, we will consider both original and review articles that focus on role of ROS in atherosclerosis. We look forward to receiving your contributions.
Dr. Weibin Shi
Guest Editor
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Keywords
- atherosclerosis
- coronary artery disease
- reactive oxygen species (ROS)
- reactive nitrogen species (RNS)
- free radical
- oxidative stress
- antioxidant
- lipid peroxidation
- inflammation
