The Role of Inflammation in Atherosclerosis and Coronary Artery Disease—2nd Edition
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 10 August 2024 | Viewed by 92
Special Issue Editor
Interests: molecular and genetic determinants of atherosclerosis; cardiometabolic disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Atherosclerosis is the pathological basis of coronary artery disease, ischemic stroke, and peripheral arterial disease. Despite optimal treatment with drugs to alleviate hyperlipidemia as well as hypertension and prevent thrombotic complications, this disease continues to be a leading cause of morbidity and mortality worldwide. Thus, there is a medical need for understanding the pathogenesis of atherosclerosis and finding new targets with which to combat the disease.
Inflammation is a key process that drives the initiation, progression, and even rupture of atherosclerotic plaques. Dyslipidemia, hypertension, obesity, and type 2 diabetes have been identified as major risk factors for atherosclerosis. These conditions are closely linked and are often concomitant with inflammation or exacerbate pre-existing inflammation. Recent evidence links the above conditions to the activation of pro-inflammatory molecules accelerating atherosclerosis. There is also evidence on the role of genetic factors in the production of pro-inflammatory molecules during atherogenesis. Deciphering the crosstalk between major risk factors and inflammation in atherosclerosis should lead to a better understanding of the pathophysiological mechanisms and would help in identifying new targets in addition to developing better therapeutical strategies for treatment.
In this Special Issue, we will consider both original and review articles that center on the molecular and genetic aspects of inflammation in atherosclerosis. We look forward to receiving your contributions.
Dr. Weibin Shi
Guest Editor
Manuscript Submission Information
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Keywords
- atherosclerosis
- coronary artery disease
- inflammation
- cytokines
- white blood cells
- monocyte
- macrophage
- adhesion molecule
- chemokines
- thrombosis
- diabetes
